Evidence map›Paper›PMID 36936287›Full record

ArticleACS omega2023

Thiol Quantification Using Colorimetric Thiol-Disulfide Exchange in Nonaqueous Solvents.

Ryan Schmidt, Matthew G Logan, Sarah Patty, Jack L Ferracane, Carmem S Pfeifer, Alexander J Kendall

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ryan SchmidtBiomaterials and Biomechanics, School of Dentistry, Oregon Health & Sciences University, 2730 S Moody Ave., Portland, Oregon 97201, United States.
Matthew G LoganBiomaterials and Biomechanics, School of Dentistry, Oregon Health & Sciences University, 2730 S Moody Ave., Portland, Oregon 97201, United States.
Sarah PattyBiomaterials and Biomechanics, School of Dentistry, Oregon Health & Sciences University, 2730 S Moody Ave., Portland, Oregon 97201, United States.
Jack L FerracaneBiomaterials and Biomechanics, School of Dentistry, Oregon Health & Sciences University, 2730 S Moody Ave., Portland, Oregon 97201, United States.
Carmem S PfeiferBiomaterials and Biomechanics, School of Dentistry, Oregon Health & Sciences University, 2730 S Moody Ave., Portland, Oregon 97201, United States.ORCID https://orcid.org/0000-0002-1587-3838
Alexander J KendallBiomaterials and Biomechanics, School of Dentistry, Oregon Health & Sciences University, 2730 S Moody Ave., Portland, Oregon 97201, United States.ORCID https://orcid.org/0000-0001-7685-481X
Oregon Health & Science University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A careful analysis of two (thiol-disulfide exchange) thiol quantification chromophores' behavior (Ellman's reagent and Aldrithiol-4) in nonaqueous solvents is presented. A wide range of kinetic profiles and response factors were measured to exhibit a large variance for nonaqueous systems. We report several robust benchtop and room-temperature methods using different organic solvents compared to aqueous conditions. Validation of analytical analyses in nonaqueous systems and quantification of the cysteine content of ovalbumin are also presented. This work serves as a treatise on the utilization of thiol-disulfide exchange chromophores under nonaqueous conditions for the quantification of thiols.

Identifiers

PMID36936287
PMCPMC10018523
OpenAlexW4322626771

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.