Evidence map›Paper›PMID 36936231›Full record

ArticleFrontiers in medicine2023

Inflammasome activation and formation of ASC specks in patients with juvenile idiopathic arthritis.

Nico Wittmann, Neha Mishra, Jana Gramenz, Daniela Kuthning, Ann-Kathrin Behrendt, Lukas Bossaller, Almut Meyer-Bahlburg

Open access · goldFull text read
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In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nico WittmannSection of Pediatric Rheumatology, Department Pediatric and Adolescent Medicine, University Medicine, University of Greifswald, Greifswald, Germany.
Neha MishraSection of Rheumatology, Department of Medicine A, University Medicine, University of Greifswald, Greifswald, Germany.
Jana GramenzSection of Pediatric Rheumatology, Department Pediatric and Adolescent Medicine, University Medicine, University of Greifswald, Greifswald, Germany.
Daniela KuthningSection of Pediatric Rheumatology, Department Pediatric and Adolescent Medicine, University Medicine, University of Greifswald, Greifswald, Germany.
Ann-Kathrin BehrendtSection of Pediatric Rheumatology, Department Pediatric and Adolescent Medicine, University Medicine, University of Greifswald, Greifswald, Germany.
Lukas BossallerSection of Rheumatology, Department of Medicine A, University Medicine, University of Greifswald, Greifswald, Germany.
Almut Meyer-BahlburgSection of Pediatric Rheumatology, Department Pediatric and Adolescent Medicine, University Medicine, University of Greifswald, Greifswald, Germany.
Universität Greifswald · DEUniversitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The formation of large intracellular protein aggregates of the inflammasome adaptor ASC is a hallmark of inflammasome activation and characteristic of autoinflammation. Inflammasome activated cells release the highly proinflammatory cytokine IL-1β in addition to ASC specks into the extracellular space. Autoinflammatory activity has been demonstrated in systemic JIA, however minimal data exist on the role of inflammasomes in other JIA subtypes. We therefore investigated, if pyroptotic cells are present in the circulation of oligo- and poly-articular JIA. Methods: Peripheral blood of JIA patients ( Results: Oligo-articular JIA patients showed a significantly increased proportion of ASC speck Conclusion: For the first time, we detect

Indexed as

apoptosis-associated speck-like protein (ASC)autoinflammationflow cytometry – methodsinflammasomejuvenile idiopathic arthritis

Identifiers

PMID36936231
PMCPMC10014801
OpenAlexW4322620728

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read22
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.