ReviewFrontiers in medicine2023
Progesterone, cerclage, pessary, or acetylsalicylic acid for prevention of preterm birth in singleton and multifetal pregnancies - A systematic review and meta-analyses.
Review in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Can universal cervical length screening with vaginal progesterone for a short cervix reduce preterm birth? A systematic review and meta-analyses.Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- Prognostic value of cervical length for spontaneous preterm birth in asymptomatic women with singleton pregnancy: An individual participant data meta-analysis.PLoS medicine · 2026Pooled it
- Oral Lacticaseibacillus rhamnosus GG Exposure During Pregnancy and Effects on Maternal Inflammatory Response-A Blinded, Pilot Randomized, Placebo-Controlled Study.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Trial
- Universal cervical length screening and vaginal progesterone: Distinguishing strategy effectiveness from treatment efficacy.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Associations of Cervical Features and Preventive Interventions With Gestational Age at Delivery.Cureus · 2026Article
- Pregnancy outcomes after ultrasound- and physical examination-indicated cervical cerclage: a retrospective cohort study.Archives of gynecology and obstetrics · 2026Article
- When belief drives practice: The case of cervical cerclage.Pregnancy (Hoboken, N.J.) · 2026Article
- Laparoscopic cervical cerclage and pregnancy outcomes in consecutive pregnancies: An observational study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Comparative Effectiveness of Pessary Placement, Cervical Cerclage, or Expectant Management in Preventing Preterm Delivery in Twin Pregnancies.Journal of personalized medicine · 2026Article
- Article
- Timing of progesterone treatment to prevent preterm birth in pregnancies with a short cervix: A population-based historical cohort study.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Women's health and maternal care services: seizing missed opportunities to prevent and manage preterm birth.Reproductive health · 2025Review
- Pessary for Prevention of Preterm Birth and Perinatal Mortality in Pregnancies with a Short Cervix: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Diagnostics (Basel, Switzerland) · 2025Review
- Global, regional, and national burden of congenital musculoskeletal and limb anomalies, 1990-2021: a systematic analysis of the global burden of disease in 2021.Tropical medicine and health · 2025Article
- Preterm birth in assisted reproduction: the mediating role of hypertensive disorders in pregnancy.Human reproduction (Oxford, England) · 2025Article
- Pessary or cerclage (PC study) to prevent recurrent preterm birth: a non-inferiority, randomised controlled trial.EClinicalMedicine · 2024Article
- Epigenetic biomarker for preeclampsia-associated preterm birth and potential preventative medicine.Environmental epigenetics · 2024Article
- Assessment of current biomarkers and interventions to identify and treat women at risk of preterm birth.Frontiers in medicine · 2024Review
- Primary prevention with vaginal chlorhexidine before 16 weeks reduces the incidence of preterm birth: results of the Preterm Labor Prevention Using Vaginal Antiseptics study.AJOG global reports · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Preterm birth is the leading cause of childhood mortality and morbidity. We aimed to provide a comprehensive systematic review on randomized controlled trials (RCTs) on progesterone, cerclage, pessary, and acetylsalicylic acid (ASA) to prevent preterm birth in asymptomatic women with singleton pregnancies defined as risk of preterm birth and multifetal pregnancies. Methods: Six databases (including PubMed, Embase, Medline, the Cochrane Library) were searched up to February 2022. RCTs published in English or Scandinavian languages were included through a consensus process. Abstracts and duplicates were excluded. The trials were critically appraised by pairs of reviewers. The Cochrane risk-of-bias tool was used for risk of bias assessment. Predefined outcomes including preterm birth, perinatal/neonatal/maternal mortality and morbidity, were pooled in meta-analyses using RevMan 5.4, stratified for high and low risk of bias trials. The certainty of evidence was assessed using the GRADE approach. The systematic review followed the PRISMA guideline. Results: The search identified 2,309 articles, of which 87 were included in the assessment: 71 original RCTs and 16 secondary publications with 23,886 women and 32,893 offspring. Conclusions were based solely on trials with low risk of bias ( Conclusion: Progesterone and probably also cerclage have a protective effect against preterm birth in asymptomatic women with a singleton pregnancy at risk of preterm birth. Further trials of ASA are needed. Prevention of preterm birth requires screening programs to identify women at risk of preterm birth. Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/], identifier [CRD42021234946].
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.