ArticleFrontiers in endocrinology2023
The role of obesity in sarcopenia and the optimal body composition to prevent against sarcopenia and obesity.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06298825 (Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure), which is not on this map. Cited by 54 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure: a Prospective, Multi-center, Observational Cohort Study
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Abnormal body weight and risk of gallbladder cancer: an updated meta-analysis incorporating recent evidence.BMC cancer · 2026Pooled it
- Visceral fat area as a prognostic biomarker in gastric cancer: a systematic review and meta-analysis of survival outcomes.Frontiers in oncology · 2025Pooled it
- Effect of a 16-Week Exercise Program After Bariatric Surgery on Sarcopenia Parameters Based on FNIH, EWGSOP2, and EASO/ESPEN Criteria: the Results of the EXPOBAR Randomized Trial Program.Obesity surgery · 2025Trial
- The impact of bariatric surgery and exercise on systemic immune inflammation index in patients with sarcopenia obesity.Scientific reports · 2025Trial
- Bioimpedance: From Body Composition Assessment to Emerging Technologies in Clinical Nutrition.Nutrients · 2026Review
- Dietary patterns and the progression from obesity to sarcopenic obesity in older adults: a prospective cohort study.BMC geriatrics · 2026Article
- Prevalence of sarcopenia and population attributable fraction of related factors in Iranian older adults from the IMOS‑2021 study.Scientific reports · 2026Article
- Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients.World journal of gastrointestinal oncology · 2026Article
- A Systematic Review and Meta-Analysis of Efficacy and Safety of Liraglutide in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Prevalence and longitudinal development of sarcopenic obesity in an Asian obese population: a large bioelectrical impedance analysis study.Frontiers in nutrition · 2026Article
- Association between CVAI-defined body composition phenotypes and prediabetes outcomes in Chinese adults undergoing health check-ups: a cross-sectional study.Frontiers in nutrition · 2026Article
- A simple score of sarcopenic obesity predicts all-cause mortality in patients with cirrhosis.Frontiers in medicine · 2026Article
- Unseen burden: Prevalence and determinants of possible sarcopenia in Indonesian older adults - a secondary data analysis.Belitung nursing journal · 2026Article
- Associations between body composition phenotypes and physical function in community-dwelling older adults: an exploratory analysis of limb muscle mass asymmetry.Frontiers in medicine · 2026Article
- Associations Between the Severity of Sarcopenia and Health-Related Quality of Life in Older Adults.Journal of clinical medicine · 2025Article
- Relationship between eating awareness, physical fitness, and body composition in community-living older adults: a cross-sectional study.BMC public health · 2025Article
- Prevalence and association of sarcopenic obesity with locomotive syndrome based on the 2024 Consensus Statement of the Japanese Working Group on Sarcopenic Obesity in community-dwelling Japanese women.Journal of physical therapy science · 2025Article
- The association between body fat distribution and osteosarcopenia in older adults: evidence from the PoCOsteo study.Aging clinical and experimental research · 2025Article
- Sarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Indicators of mortality risk in ageing horses.GeroScience · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Elderly people with low lean and high fat mass, are diagnosed with sarcopenic obesity (SO), and often have poor clinical outcomes. This study aimed to explore the relationship between obesity and sarcopenia, and the optimal proportion of fat and muscle for old individuals. Methods: Participants aged 60 years or above were instructed to perform bioelectrical impedance analysis to obtain the muscle and fat indicators, and handgrip strength was also performed. Sarcopenia was diagnosed according to predicted appendicular skeletal muscle mass and function. Body mass index (BMI) and body fat percentage (BF%) were used to define obesity. The association of muscle and fat indicators were analyzed by Pearson's correlation coefficient. Pearson Chi-Square test was utilized to estimate odds ratios (OR) and 95% confidence intervals (CI) on the risk of sarcopenia according to obesity status. Results: 1637 old subjects (74.8 ± 7.8 years) participated in this study. Not only fat mass, but also muscle indicators were positively correlated to BMI and body weight (p < 0.05). Absolute muscle and fat mass in different positions had positive associations (p < 0.05). Muscle mass and strength were negatively related to appendicular fat mass percentage (p < 0.05). When defined by BMI (OR = 0.69, 95% CI [0.56, 0.86]; p = 0.001), obesity was a protective factor for sarcopenia, whilst it was a risk factor when using BF% (OR = 1.38, 95% CI [1.13, 1.69]; p = 0.002) as the definition. The risk of sarcopenia reduced with the increase of BMI in both genders. It was increased with raised BF% in males but displayed a U-shaped curve for females. BF% 26.0-34.6% in old females and lower than 23.9% in old males are recommended for sarcopenia and obesity prevention. Conclusion: Skeletal muscle mass had strong positive relationship with absolute fat mass but negative associations with the percentage of appendicular fat mass. Obesity was a risk factor of sarcopenia when defined by BF% instead of BMI. The management of BF% can accurately help elderly people prevent against both sarcopenia and obesity.
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