Evidence map›Paper›PMID 36936174›Full record

ArticleFrontiers in endocrinology2023

Identification of altered miRNAs and their targets in placenta accreta.

José M Murrieta-Coxca, Emanuel Barth, Paulina Fuentes-Zacarias, Ruby N Gutiérrez-Samudio, Tanja Groten, Alexandra Gellhaus, Angela Köninger, Manja Marz, Udo R Markert, Diana M Morales-Prieto

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In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

José M Murrieta-CoxcaDepartment of Obstetrics, Placenta Lab, Jena University Hospital, Jena, Germany.
Emanuel BarthFriedrich Schiller University Jena, Faculty of Mathematics and Computer Science, RNA Bioinformatics and High Throughput Analysis, Jena, Germany.
Paulina Fuentes-ZacariasDepartment of Obstetrics, Placenta Lab, Jena University Hospital, Jena, Germany.
Ruby N Gutiérrez-SamudioDepartment of Obstetrics, Placenta Lab, Jena University Hospital, Jena, Germany.
Tanja GrotenDepartment of Obstetrics, Placenta Lab, Jena University Hospital, Jena, Germany.
Alexandra GellhausDepartment of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany.
Angela KöningerDepartment of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany.
Manja MarzFriedrich Schiller University Jena, Faculty of Mathematics and Computer Science, RNA Bioinformatics and High Throughput Analysis, Jena, Germany.
Udo R MarkertDepartment of Obstetrics, Placenta Lab, Jena University Hospital, Jena, Germany.
Diana M Morales-PrietoDepartment of Obstetrics, Placenta Lab, Jena University Hospital, Jena, Germany.
Jena University Hospital · DEUniversity of Duisburg-Essen · DEFriedrich Schiller University Jena · DELeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Placenta accreta spectrum (PAS) is one of the major causes of maternal morbidity and mortality worldwide with increasing incidence. PAS refers to a group of pathological conditions ranging from the abnormal attachment of the placenta to the uterus wall to its perforation and, in extreme cases, invasion into surrounding organs. Among them, placenta accreta is characterized by a direct adhesion of the villi to the myometrium without invasion and remains the most common diagnosis of PAS. Here, we identify the potential regulatory miRNA and target networks contributing to placenta accreta development. Using small RNA-Seq followed by RT-PCR confirmation, altered miRNA expression, including that of members of placenta-specific miRNA clusters (e.g., C19MC and C14MC), was identified in placenta accreta samples compared to normal placental tissues.

Indexed as

MicroRNAsPlacenta AccretaEndothelial CellsFemaleHumansMyometriumPlacentaPregnancyMicroRNAsmicroRNAmiRNA targetsmRNAplacentaplacenta accreta spectrumpregnancyRNA-sequencingtrophoblast

Identifiers

PMID36936174
PMCPMC10022468
OpenAlexW4323041668

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.