ArticleAdvances in methods and practices in psychological science
Hybrid Experimental Designs for Intervention Development: What, Why, and How.
Article in Advances in methods and practices in psychological science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
- Theory-based promotion of diet and transportation behavior change to reduce carbon footprint among students: Randomized parallel trial of the GROW app.Applied psychology. Health and well-being · 2026Trial
- Effect of a Digital Health Physical Activity Program Integrating Gamification for Obesity Management in Comparison With Usual Care: Randomized Controlled Trial With an Ideographic Approach.Journal of medical Internet research · 2025Trial
- Adaptive interventions for alcohol misuse and violent behaviors among adolescents and emerging adults in the emergency department: Outcomes from a sequential multiple assignment randomized controlled trial.Drug and alcohol dependence · 2025Trial
- Mobile intervention for emerging adults with regular cannabis use: a micro-randomized trial.Lancet regional health. Americas · 2026Article
- Combination treatment for chronic insomnia disorder in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Review
- Just-in-Time Adaptive Interventions: Where Are We Now and What Is Next?Annual review of psychology · 2026Review
- Daily web survey data collection of time-varying cannabis use motives and contexts, with implications for adaptive interventions: A pilot study.Drug and alcohol dependence · 2026Article
- Digital Integrated Interventions for Comorbid Depression and Substance Use Disorder: Narrative Review and Content Analysis.JMIR mental health · 2025Review
- A national evaluation of a multi-modal, blended, digital intervention integrated within Australian youth mental health services.Acta psychiatrica Scandinavica · 2025Article
- Effective engagement in computerized cognitive training for older adults.Ageing research reviews · 2025Review
- The recent history and near future of digital health in the field of behavioral medicine: an update on progress from 2019 to 2024.Journal of behavioral medicine · 2025Review
- What was done for youths aged 15 to 24 around the world? A systematic review of worldwide mental health interventions.Global mental health (Cambridge, England) · 2025Review
- Realizing the potential of mobile interventions for education.NPJ science of learning · 2024Review
- A health-equity framework for tailoring digital non-pharmacological interventions in aging.Nature. Mental health · 2024Article
- Latent transition analysis of time-varying cannabis use motives to inform adaptive interventions.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024Article
- Towards the Science of Engagement with Digital Interventions.Current directions in psychological science · 2024Article
- Intervention Optimization: A Paradigm Shift and Its Potential Implications for Clinical Psychology.Annual review of clinical psychology · 2024Review
- Mobile Health Interventions for Substance Use Disorders.Annual review of clinical psychology · 2024Review
- Optimizing an adaptive digital oral health intervention for promoting oral self-care behaviors: Micro-randomized trial protocol.Contemporary clinical trials · 2024Article
- Digital Adaptive Behavioral Interventions to Improve HIV Prevention and Care: Innovations in Intervention Approach and Experimental Design.Current HIV/AIDS reports · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Advances in mobile and wireless technologies offer tremendous opportunities for extending the reach and impact of psychological interventions and for adapting interventions to the unique and changing needs of individuals. However, insufficient engagement remains a critical barrier to the effectiveness of digital interventions. Human delivery of interventions (e.g., by clinical staff) can be more engaging but potentially more expensive and burdensome. Hence, the integration of digital and human-delivered components is critical to building effective and scalable psychological interventions. Existing experimental designs can be used to answer questions either about human-delivered components that are typically sequenced and adapted at relatively slow timescales (e.g., monthly) or about digital components that are typically sequenced and adapted at much faster timescales (e.g., daily). However, these methodologies do not accommodate sequencing and adaptation of components at multiple timescales and hence cannot be used to empirically inform the joint sequencing and adaptation of human-delivered and digital components. Here, we introduce the hybrid experimental design (HED)-a new experimental approach that can be used to answer scientific questions about building psychological interventions in which human-delivered and digital components are integrated and adapted at multiple timescales. We describe the key characteristics of HEDs (i.e., what they are), explain their scientific rationale (i.e., why they are needed), and provide guidelines for their design and corresponding data analysis (i.e., how can data arising from HEDs be used to inform effective and scalable psychological interventions).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.