Evidence map›Paper›PMID 36935610›Full record

ArticleAutism : the international journal of research and practice2023

Distinct patterns of GABAergic interneuron pathology in autism are associated with intellectual impairment and stereotypic behaviors.

Brett D Dufour, Erin McBride, Trevor Bartley, Pablo Juarez, Verónica Martínez-Cerdeño

Open access · greenAbstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Brett D DufourUC Davis Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, Sacramento, CA, USA.
Erin McBrideInstitute for Pediatric Regenerative Medicine (IPRM), Shriner's Hospital for Children and UC Davis School of Medicine, Sacramento, CA, USA.
Trevor BartleyInstitute for Pediatric Regenerative Medicine (IPRM), Shriner's Hospital for Children and UC Davis School of Medicine, Sacramento, CA, USA.
Pablo JuarezInstitute for Pediatric Regenerative Medicine (IPRM), Shriner's Hospital for Children and UC Davis School of Medicine, Sacramento, CA, USA.
Verónica Martínez-CerdeñoInstitute for Pediatric Regenerative Medicine (IPRM), Shriner's Hospital for Children and UC Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-9613-3603
Shriners Hospitals for Children - Erie · US

Funding

Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2019
$8.5M
Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
Cortical and subcortical chandelier cell pathophysiology and symptomatology in autismR01MH094681 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Veronica Martinez-Cerdeno · 2011 to 2026
$6.5M
NICHD NIH HHS U54 HD079125NIMH NIH HHS R01 MH094681NIMH NIH HHS T32 MH073124
6 · The paper itself

Abstract

lay abstractAutism spectrum disorder is a neurodevelopmental condition characterized by deficits in sociability and communication and the presence of repetitive behaviors. How specific pathological alterations of the brain contribute to the clinical profile of autism spectrum disorder remains unknown. We previously found that a specific type of inhibitory interneuron is reduced in number in the autism spectrum disorder prefrontal cortex. Here, we assessed the relationship between interneuron reduction and autism spectrum disorder symptom severity. We collected clinical records from autism spectrum disorder (

Indexed as

Autism Spectrum DisorderAutistic DisorderBrainHumansInterneuronsStereotyped Behaviorautismbehaviorhumaninterneuronpostmortem

Identifiers

PMID36935610
PMCPMC10846597
OpenAlexW4327898050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.