ArticleUltrasonography (Seoul, Korea)2023
Combined fine-needle aspiration with core needle biopsy for assessing thyroid nodules: a more valuable diagnostic method?
Article in Ultrasonography (Seoul, Korea), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 7 citations in OpenAlex.
- AI-Assisted Papillary Thyroid Carcinoma Localization on Cervical Non-contrast CT: A Multicenter Validation and Two-Reader Pilot Study of a Standalone Executable nnU-Net Software.Journal of imaging informatics in medicine · 2026Article
- Advantages of thyroid core needle biopsy: an emerging selective first-line biopsy modality.Ultrasonography (Seoul, Korea) · 2026Article
- Clinical Value of Core Needle Biopsy as a Second-Line Approach After Non-Conclusive Fine-Needle Aspiration in Thyroid Nodules: A Paired Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Non-contrast computed tomography radiomics model to predict benign and malignant thyroid nodules with lobe segmentation: A dual-center study.World journal of radiology · 2025Article
- Do stylet needles improve diagnostic accuracy in thyroid fine-needle aspiration? A retrospective analysis.BMC endocrine disorders · 2025Article
- Lessons learned from the first 2 years of experience with thyroid core needle biopsy at an Indonesian national referral hospital.Journal of pathology and translational medicine · 2025Article
- Echogenicity as a standalone nodule characteristic is not inferior to the TIRADS systems in the 10-20 mm nodule diameter range in patient selection for fine needle aspiration: a pilot study.European thyroid journal · 2024Article
- Ultrasonographic features and diagnostic accuracy of FNA and CNB in secondary thyroid malignancies: A retrospective study.Heliyon · 2024Article
- Predictive accuracy and reproducibility of the O-RADS US scoring system among sonologists with different training levels.Archives of gynecology and obstetrics · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThis study aimed to evaluate the diagnostic value of combined fine-needle aspiration (FNA) with core needle biopsy (CNB) in thyroid nodules.
methodsFNA and CNB were performed simultaneously on 703 nodules. We compared the proportions of inconclusive results and the diagnostic performance for malignancy among FNA, CNB, and combined FNA/CNB for different nodule sizes.
resultsCombined FNA/CNB showed lower proportions of inconclusive results than CNB for all nodules (2.8% vs. 5.7%, P<0.001), nodules ≤1.0 cm (4.9% vs. 7.3%, P=0.063), nodules >1.0 cm (2.0% vs. 5.0 %, P<0.001), nodules ≤1.5 cm (3.8% vs. 7.9 %, P<0.001), and nodules >1.5 cm (2.1% vs. 3.9 %, P=0.016). The sensitivity of combined FNA/CNB in predicting malignancy was significantly higher than that of CNB (89.0% vs. 80.0%, P<0.001) and FNA (89.0% vs. 58.1%, P<0.001) for all nodules. Within American College of Radiology Thyroid and Imaging Reporting and Data System grades 4-5, in the subgroup of nodules ≤1.5 cm, combined FNA/ CNB showed the best sensitivity in predicting malignancy (91.4%), significantly higher than that of CNB (81.0%, P<0.001) and FNA (57.8%, P<0.001). However, in the subgroup of nodules >1.5 cm, the difference between combined FNA/CNB and CNB was not significant (84.2% vs. 78.9%, P=0.500).
conclusionRegardless of nodule size, combined FNA/CNB tended to yield lower proportions of inconclusive results than CNB or FNA alone and exhibited higher performance in diagnosing malignancy. The combined FNA/CNB technique may be a more valuable diagnostic method for nodules ≤1.5 cm and nodules with a risk of malignancy than CNB and FNA alone.
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