Evidence map›Paper›PMID 36935339›Full record

ArticleTrends in parasitology2023

Liver-stage Plasmodium infection tunes clinical outcomes.

Alexis Kaushansky, Nana Minkah

Open access · greenAbstract read
In one paragraph

Article in Trends in parasitology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexis KaushanskyDepartment of Pediatrics, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA. Electronic address: alexis.kaushansky@seattlechildrens.org.
Nana MinkahDepartment of Pediatrics, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA. Electronic address: nana.minkah@seattlechildrens.org.
University of Washington · US

Funding

Mechanisms of endothelial dysfunction in cerebral malaria and barrier restorative pathwaysR01AI148802 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI SMITH, JOSEPH D · 2020 to 2024
$3.5M
Perturbations of host cell signaling by a complex hepatotropic pathogenR01AI177257 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Alexis Kaushansky · 2023 to 2026
$2.6M
NIAID NIH HHS R01 AI148802NIAID NIH HHS R01 AI177257
6 · The paper itself

Abstract

Chora and colleagues show that infection of the liver by Plasmodium modulates severity of disease in the experimental cerebral malaria (ECM) model by generating gamma delta (ɣδ) T cells that produce IL-17. This work calls into question the long-standing assumption that liver infection does not modulate severity of malaria.

Indexed as

Communicable DiseasesLiver DiseasesMalaria, CerebralHumansPlasmodium bergheierythropoiesisexperimental cerebral malariaɣδ T cellIL-17liver-stage Plasmodium immunitynatural immunity to malaria

Identifiers

PMID36935339
PMCPMC10634323
OpenAlexW4327705410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.