Evidence map›Paper›PMID 36934358›Full record

ArticleArchives of microbiology2023

Exploring the antibacterial potential of venoms from Argentinian animals.

Micaela A Gritti, Karen Y González, Flavio L Tavares, Gladys P Teibler, María E Peichoto

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Micaela A GrittiConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Karen Y GonzálezConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Flavio L TavaresUniversidade Federal da Integração Latino-Americana (UNILA), Av. Tarquínio Joslin dos Santos, nº. 1.000, Jd. Universitário, Foz do Iguaçu, PR, CEP 85870-901, Brazil.
Gladys P TeiblerFacultad de Ciencias Veterinarias (FCV), Universidad Nacional del Nordeste (UNNE), Sargento Cabral 2139, 3400, Corrientes, Argentina.
María E PeichotoConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. mepeichoto@yahoo.com.ar.
Universidade Federal da Integração Latino-Americana · BRConsejo Nacional de Investigaciones Científicas y Técnicas · ARInstituto Nacional de Medicina Tropical · ARNational University of the Northeast · AR

Funding

AGENCIA I+D+i from Argentina PICT-2020-SERIEA-02027
6 · The paper itself

Abstract

The resistance to antimicrobials developed by several bacterial species has become one of the main health problems in recent decades. It has been widely reported that natural products are important sources of antimicrobial compounds. Considering that animal venoms are under-explored in this line of research, in this study, we screened the antibacterial activity of venoms of eight snake and five lepidopteran species from northeastern Argentina. Twofold serial dilutions of venoms were tested by the agar well-diffusion method and the minimum inhibitory concentration (MIC) determination against seven bacterial strains. We studied the comparative protein profile of the venoms showing antibacterial activity. Only the viperid and elapid venoms showed remarkable dose-dependent antibacterial activity towards most of the strains tested. Bothrops diporus venom showed the lowest MIC values against all the strains, and S. aureus ATCC 25923 was the most sensitive strain for all the active venoms. Micrurus baliocoryphus venom was unable to inhibit the growth of Enterococcus faecalis. Neither colubrid snake nor lepidopteran venoms exhibited activity on any bacterial strain tested. The snake venoms exhibiting antibacterial activity showed distinctive protein profiles by SDS-PAGE, highlighting that we could reveal for the first time the main protein families which may be thought to contribute to the antibacterial activity of M. baliocoryphus venom. This study paves the way to search for new antibacterial agents from Argentinian snake venoms, which may be a further opportunity to give an added value to the local biodiversity.

Indexed as

Snake VenomsStaphylococcus aureusAnimalsAnti-Bacterial AgentsArgentinaBacteriaAnti-Bacterial AgentsSnake VenomsAntimicrobialBioprospectionLepidopteraSerpentesVenom

Identifiers

PMID36934358
OpenAlexW4327857969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.