Evidence map›Paper›PMID 36934325›Full record

ArticleCell reports2023

Inter-axonal molecular crosstalk via Lumican proteoglycan sculpts murine cervical corticospinal innervation by distinct subpopulations.

Yasuhiro Itoh, Vibhu Sahni, Sara J Shnider, Holly McKee, Jeffrey D Macklis

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The extracellular matrix genebioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Corticospinal Tract Development, Evolution, and Skilled Movements.Movement disorders : official journal of the Movement Disorder Society · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yasuhiro ItohDepartment of Stem Cell and Regenerative Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Vibhu SahniDepartment of Stem Cell and Regenerative Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Sara J ShniderDepartment of Stem Cell and Regenerative Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Holly McKeeDepartment of Stem Cell and Regenerative Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Jeffrey D MacklisDepartment of Stem Cell and Regenerative Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: jeffrey_macklis@harvard.edu.
Harvard University · USHarvard Stem Cell Institute · US

Funding

Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and RegenerationDP1NS106665 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2017 to 2021
$5.9M
Molecular Controls over Neurogenesis, Subtype Development, and Diversity of Cortical Output Projection NeuronsR01NS045523 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2002 to 2020
$5.4M
Neurorehabilitation and Restorative Neuroscience NetworkK12HD093427 · NICHD · GEORGETOWN UNIVERSITY · PI BREGMAN, BARBARA S, DROMERICK, ALEXANDER W · 2017 to 2021
$3.9M
Molecular Development and Diversity of Callosal Projection NeuronsR01NS104055 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2020 to 2024
$1.9M
Molecular Mechanisms of CTIP2 Function in Corticospinal Motor Neuron DevelopmentR01NS075672 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2012 to 2016
$1.8M
Cortico-Spinal Repopulation from Precursors for RepairR01NS049553 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2004 to 2007
$1.6M
Molecular Determinants of Corticospinal Motor Neuron Segmental Target SpecificityF31NS063516 · NINDS · HARVARD UNIVERSITY · PI SHNIDER, SARA JUDITH · 2008 to 2009
$36k
NICHD NIH HHS K12 HD093427NINDS NIH HHS DP1 NS106665NINDS NIH HHS F31 NS063516NINDS NIH HHS R01 NS045523NINDS NIH HHS R01 NS049553NINDS NIH HHS R01 NS075672NINDS NIH HHS R01 NS104055
6 · The paper itself

Abstract

How CNS circuits sculpt their axonal arbors into spatially and functionally organized domains is not well understood. Segmental specificity of corticospinal connectivity is an exemplar for such regional specificity of many axon projections. Corticospinal neurons (CSN) innervate spinal and brainstem targets with segmental precision, controlling voluntary movement. Multiple molecularly distinct CSN subpopulations innervate the cervical cord for evolutionarily enhanced precision of forelimb movement. Evolutionarily newer CSN

Indexed as

AxonsSpinal CordAnimalsLumicanMiceMovementNeuronsPyramidal TractsLumicanaxon collateralizationaxon developmentcircuit refinementcorticospinal neuronscorticospinal segmental specificityCP: Neuroscienceevolutionary circuit diversificationforelimb dexterityinter-axonal molecular crosstalkLumican proteoglycan

Identifiers

PMID36934325
PMCPMC10167627
OpenAlexW4327719435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.