Evidence map›Paper›PMID 36934308›Full record

SynthesisGynecologic oncology2023

Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium: An individual-participant meta-analysis.

Theodore M Brasky, Erinn M Hade, David E Cohn, Alison M Newton, Stacey Petruzella, Kelli O'Connell, Kimberly A Bertrand, Linda S Cook, Immaculata De Vivo, Mengmeng Du and 27 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gynecologic oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. History of Infertility and Risk of Endometrial Cancer in the Women's Health Initiative.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 6 countries.

Theodore M BraskyDepartment of Internal Medicine, Division of Medical Oncology, The Ohio State University College of Medicine, Columbus, OH, USA. Electronic address: Theodore.Brasky@osumc.edu.
Erinn M HadeDepartment of Internal Medicine, Division of Medical Oncology, The Ohio State University College of Medicine, Columbus, OH, USA; Department of Population Health, Division of Biostatistics, New York University Grossman School of Medicine, New York, NY, USA.
David E CohnDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Columbus, OH, USA.
Alison M NewtonDepartment of Internal Medicine, Division of Medical Oncology, The Ohio State University College of Medicine, Columbus, OH, USA.
Stacey PetruzellaDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kelli O'ConnellDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kimberly A BertrandSlone Epidemiology Center at Boston University, Boston University School of Medicine, Boston, MA, USA.
Linda S CookDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.
Immaculata De VivoDepartment of Epidemiology, Harvard University, Boston, MA, USA.
Mengmeng DuDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jo L FreudenheimDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, USA.
Christine M FriedenreichCancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, AB, Canada; Departments of Oncology and Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.
Marc T GoodmanDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Jessica GorzelitzMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Torukiri I IbiebelePopulation Health Department, QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.
Vittorio KroghFondazione IRCCS - Istituto Nazionale dei Tumori di Milan, Milan, Italy.
Linda M LiaoMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute USA, Bethesda, MD, USA.
Loren LipworthDepartment of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Lingeng LuDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Susan McCannCancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Tracy A O'MaraComputational Biology and Genetics Department, QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.
Julie R PalmerSlone Epidemiology Center at Boston University, Boston University School of Medicine, Boston, MA, USA.
Jeanette PonteDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Anna PrizmentDepartment of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.
Harvey RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Sven SandinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Seaver Autism Center for Research and Treatment at Mount Sinai, New York, NY, USA.
Leo J SchoutenDepartment of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
Veronica Wendy SetiawanDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Xiao-Ou ShuDepartment of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Britton TrabertMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT, USA.
Piet A van den BrandtDepartment of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
Penelope M WebbPopulation Health Department, QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.
Nicolas WentzensenClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute USA, Rockville, MD, USA.
Lynne R WilkensCancer Center, University of Hawaii, Honolulu, HI, USA.
Alicja WolkInstitute of Environmental Medicine, Unit of Cardiovascular and Nutritional Epidemiology, Karolinska Institute, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Herbert YuEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Marian L NeuhouserCancer Prevention Program, Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Memorial Sloan Kettering Cancer Center · USKarolinska Institutet · SENational Cancer Institute · USQIMR Berghofer Medical Research Institute · AUBoston University · USMaastricht University · NLUniversity of Hawaiʻi at Mānoa · USUppsala University · SEVanderbilt University Medical Center · USYale University · USCedars-Sinai Medical Center · USColumbus Community Clinical Oncology Program · USFondazione IRCCS Istituto Nazionale dei Tumori · ITHarvard University · USHuntsman Cancer Institute · USRoswell Park Comprehensive Cancer Center · USThe Ohio State University · USUniversity at Buffalo, State University of New York · USUniversity of Calgary · CAUniversity of Minnesota · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
A Follow-up Study for Causes of Cancer in Black WomenU01CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kimberly A. Bertrand, Yvette C Cozier · 2017 to 2026
$24.0M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
Prospective Studies of Diet and Cancer in the AARP CohortZIACP010196 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SINHA, RASHMI · 2009 to 2025
$21.0M
FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7M
VALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
$18.5M
EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENR01CA039742 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LAZOVICH, DEANN · 1985 to 2014
$8.0M
Intramural NIH HHS Z01 CP010196Intramural NIH HHS ZIA CP010196NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA039742NCI NIH HHS R01 CA058420NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA082838NCI NIH HHS R01 CA083918NCI NIH HHS R01 CA098346NCI NIH HHS R03 CA135632NCI NIH HHS R03 CA169888NCI NIH HHS R03 CA212808NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA164974NCI NIH HHS U01 CA202979NCI NIH HHS U01 CA250476NHLBI NIH HHS HHSN268201000046CNHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100046CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

backgroundLimited data from prospective studies suggest that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA), which hold anti-inflammatory properties, may reduce endometrial cancer risk; particularly among certain subgroups characterized by body mass and tumor pathology. MATERIALS AND

methodsData from 12 prospective cohort studies participating in the Epidemiology of Endometrial Cancer Consortium were harmonized as nested case-control studies, including 7268 endometrial cancer cases and 26,133 controls. Habitual diet was assessed by food frequency questionnaire, from which fatty acid intakes were estimated. Two-stage individual-participant data mixed effects meta-analysis estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) through logistic regression for associations between study-specific energy-adjusted quartiles of LCn3PUFA and endometrial cancer risk.

resultsWomen with the highest versus lowest estimated dietary intakes of docosahexaenoic acid, the most abundant LCn3PUFA in diet, had a 9% increased endometrial cancer risk (Quartile 4 vs. Quartile 1: OR 1.09, 95% CI: 1.01-1.19; P trend = 0.04). Similar elevated risks were observed for the summary measure of total LCn3PUFA (OR 1.07, 95% CI: 0.99-1.16; P trend = 0.06). Stratified by body mass index, higher intakes of LCn3PUFA were associated with 12-19% increased endometrial cancer risk among overweight/obese women and no increased risk among normal-weight women. Higher associations appeared restricted to White women. The results did not differ by cancer grade.

conclusionHigher dietary intakes of LCn3PUFA are unlikely to reduce endometrial cancer incidence; rather, they may be associated with small to moderate increases in risk in some subgroups of women, particularly overweight/obese women.

Indexed as

Endometrial NeoplasmsFatty Acids, Omega-3DietFemaleHumansLogistic ModelsObesityOverweightProspective StudiesRisk FactorsFatty Acids, Omega-3Endometrial cancerFatty acidOmega-3PolyunsaturatedUterine cancer

Identifiers

PMID36934308
PMCPMC10025515
OpenAlexW4307721163

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.