ArticleBMC complementary medicine and therapies2023
Effect of PCL nanofiber mats coated with chitosan microcapsules containing cinnamon essential oil for wound healing.
Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Design and Evaluation of a Multicomponent Herbal Nanogel for Mosquito Repellency: An Integrated In Silico Experimental Approach AgainstJournal of tropical medicine · 2026Article
- Synthetic Polymer-Based Interventions in Wound Healing: A Clinical Perspective on their Efficacy and Limitations.Current pharmaceutical design · 2026Review
- Polycaprolactone-Based Nanocomposites for Wound Healing: Progress, Pitfalls, and Prospects.Current pharmaceutical design · 2026Review
- Cinnamon Essential Oil Delivery Systems: Preparation Processes, Packaging Forms, and Industrialization Potentials.Food science & nutrition · 2025Review
- Therapeutic potential of repaglinide-embedded chitosan hydrogel in promoting wound healing.Regenerative therapy · 2025Article
- Odor symptom management in patients with malignant wounds in Mali: the use of a cinnamon dressing.BMC cancer · 2025Observational
- Iran's Leap into the Future; an Exploration of Tissue Engineering Companies: Review Article.Iranian journal of public health · 2025Review
- Review
- Advances in Electrospun Poly(ε-caprolactone)-Based Nanofibrous Scaffolds for Tissue Engineering.Polymers · 2024Review
- Advancements in wound management: integrating nanotechnology and smart materials for enhanced therapeutic interventions.Discover nano · 2024Review
- Electrospun Poly-ε-Caprolactone Nanofibers Incorporating Keratin Hydrolysates as Innovative Antioxidant Scaffolds.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Electrospun Nanofibers Loaded with Marigold Extract Based on PVP/HPβCD and PCL/PVP Scaffolds for Wound Healing Applications.Materials (Basel, Switzerland) · 2024Article
- Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels.BMC complementary medicine and therapies · 2024Article
- Resveratrol Nanoformulation Inhibits Invasive Breast Cancer Cell Growth through Autophagy Induction: AnCell journal · 2024Article
- The wound healing effect of polycaprolactone-chitosan scaffold coated with a gel containing Zataria multiflora Boiss. volatile oil nanoemulsions.BMC complementary medicine and therapies · 2024Article
- Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing.Pharmaceutics · 2023Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCinnamon is one of the most common spices that has been studied for its anti-inflammatory, antioxidant, and antibacterial properties in wound healing. The purpose of this study was to evaluate the effectiveness of polycaprolactone nanofiber mats coated with chitosan microcapsules loaded with cinnamon essential oil in wound healing. MATERIAL AND
methodsFor this purpose, chitosan microcapsules containing cinnamon essential oil (µCS-CiZ) were prepared by ion gelation and PCL nanofibers by electrospinning. The size of the µCS-CiZ and the morphology of nanofibers were evaluated by DLS and FESEM methods. In order to evaluate wound healing, 48 rats in 4 groups of Control, µCS-CiZ, PCL, and PCL + µCS-CiZ and were examined on days 7, 14, and 21 in terms of macroscopy (wound closure rate) and histology (edema, inflammation, vascularity, fibrotic tissue, and re-epithelialization).
resultsThe particle size of the µCS-CiZ and the diameter of the nanofibers were estimated at about 6.33 ± 1.27 μm and 228 ± 33 nm, respectively. On day 21, both µCS-CiZ and PCL groups showed a significant decrease in wound size compared to the control group (P < 0.001). The PCL + µCS-CiZ group also showed a significant decrease compared to the µCS-CiZ (P < 0.05) and PCL groups (P < 0.05). Histological results showed further reduction of edema, inflammation, and vascularity in granulation tissue and appearance of moderate to marked fibrotic tissue in PCL + µCS-CiZ group compared with the other groups.
conclusionThe results of the study showed that the combined use of PCL + µCS-CiZ indicates a synergistic effect on improving wound healing.
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