ArticleThe Journal of cell biology1987
Rapidly transported organelles containing membrane and cytoskeletal components: their relation to axonal growth.
Article in The Journal of cell biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 95 citations in OpenAlex.
- Autophagy in Neurons.Annual review of cell and developmental biology · 2019Review
- βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Autophagy in C. elegans development.Developmental biology · 2019Review
- The where, what, and when of membrane protein degradation in neurons.Developmental neurobiology · 2018Review
- Neurofilaments and Neurofilament Proteins in Health and Disease.Cold Spring Harbor perspectives in biology · 2017Review
- KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses.Developmental cell · 2016Article
- Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.Brain : a journal of neurology · 2015Article
- A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.The Journal of cell biology · 2014Article
- Autophagy in axonal and dendritic degeneration.Trends in neurosciences · 2013Review
- Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Local modulation of plus-end transport targets herpesvirus entry and egress in sensory axons.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching.Molecular biology of the cell · 2001Article
- Neurofilaments are transported rapidly but intermittently in axons: implications for slow axonal transport.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Intermediate filaments on the move.The Journal of cell biology · 2000Review
- Targeted expression of truncated glued disrupts giant fiber synapse formation in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Synthesis of beta-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Rapid movements of vimentin on microtubule tracks: kinesin-dependent assembly of intermediate filament networks.The Journal of cell biology · 1998Article
- Real-time imaging of the axonal transport of granules containing a tissue plasminogen activator/green fluorescent protein hybrid.Molecular biology of the cell · 1998Article
- Visualization of the dynamics of synaptic vesicle and plasma membrane proteins in living axons.The Journal of cell biology · 1998Article
- Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons.The Journal of cell biology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have examined the movements, composition, and cellular origin of phase-dense varicosities in cultures of chick sympathetic and sensory neurons. These organelles are variable in diameter (typically between 0.2 and 2 microns) and undergo saltatory movements both towards and away from the neuronal cell body. Their mean velocities vary inversely with the size of the organelle and are greater in the retrograde than the anterograde direction. Organelles stain with the lipophilic dye 1, 1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine and with antibodies to cytoskeletal components. In cultures double-stained with antibodies to alpha-tubulin and 70-kD neurofilament protein (NF-L), approximately 40% of the organelles stain for tubulin, 30% stain for NF-L, 10% stain for both tubulin and NF-L, and 40% show no staining with either antibody. The association of cytoskeletal proteins with the organelles shows that these proteins are able to move by a form of rapid axonal transport. Under most culture conditions the predominant direction of movement is towards the cell body, suggesting that the organelles are produced at or near the growth cone. Retrograde movements continue in culture medium lacking protein or high molecular mass components and increase under conditions in which the advance of the growth cone is arrested. There is a fourfold increase in the number of organelles moving retrogradely in neurites that encounter a substratum-associated barrier to elongation; retrograde movements increase similarly in cultures exposed to cytochalasin at levels known to block growth cone advance. No previously described organelle shows behavior coordinated with axonal growth in this way. We propose that the organelles contain membrane and cytoskeletal components that have been delivered to the growth cone, by slow or fast anterograde transport, in excess of the amounts required to synthesize more axon. In view of their rapid mobility and variable contents, we suggest that they be called "neuronal parcels."
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.