Evidence map›Paper›PMID 36933998›Full record

ArticleTrends in cell biology2023

Molecular mechanisms of nucleolar DNA damage checkpoint response.

Jia Li, Shan Yan

Abstract read
In one paragraph

Article in Trends in cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Liquid-Liquid Phase Separation Sheds New Light upon Cardiovascular Diseases.International journal of molecular sciences · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jia LiDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Shan YanDepartment of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA; Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA; School of Data Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA. Electronic address: shan.yan@uncc.edu.

Funding

Mechanism of APE1 in DNA damage responseR01CA225637 · NCI · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI YAN, SHAN · 2018 to 2022
$1.9M
ATM activation by DNA single-strand breaksR21ES032966 · NIEHS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI YAN, SHAN · 2021 to 2022
$415k
Mechanism of APE2 in genome integrityR03CA270663 · NCI · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI YAN, SHAN · 2023 to 2024
$149k
NCI NIH HHS R01 CA225637NCI NIH HHS R03 CA270663NIEHS NIH HHS R21 ES032966
6 · The paper itself

Abstract

Ribosomal DNA (rDNA) is transcribed into RNA in the nucleolus and is often challenged by different stress conditions. However, the underlying mechanisms of nucleolar DNA damage response (DDR) pathways remain elusive. Here, we provide distinct perspectives on how nucleolar DDR checkpoint pathways are activated by different stresses or by liquid-liquid phase separation (LLPS).

Indexed as

Cell NucleolusDNA DamageCell Cycle CheckpointsDNA, RibosomalHumansDNA, RibosomalAPE1ATMATRDNA damage responseLLPSnucleolus

Identifiers

PMID36933998
PMCPMC10215988

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.