ArticleBrain stimulation
Quasi-static pipeline in electroconvulsive therapy computational modeling.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Computational Models of High-Definition Electroconvulsive Therapy for Focal or Multitargeting Treatment.The journal of ECT · 2025Article
- Wearable disposable electrotherapy.Nature communications · 2025Article
- Computational Optimization of Spinal Cord Stimulation for Dorsal Horn Interneuron Polarization.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- On assumptions and key issues in electric field modeling for ECT.Molecular psychiatry · 2024Article
- Quasistatic approximation in neuromodulation.Journal of neural engineering · 2024Review
- Amplitude-determined seizure-threshold, electric field modeling, and electroconvulsive therapy antidepressant and cognitive outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Towards a more accurate quasi-static approximation of the electric potential for neurostimulation with kilohertz-frequency sourcesJournal of neural engineering · 2023Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundComputational models of current flow during Electroconvulsive Therapy (ECT) rely on the quasi-static assumption, yet tissue impedance during ECT may be frequency specific and change adaptively to local electric field intensity.
objectivesWe systematically consider the application of the quasi-static pipeline to ECT under conditions where 1) static impedance is measured before ECT and 2) during ECT when dynamic impedance is measured. We propose an update to ECT modeling accounting for frequency-dependent impedance.
methodsThe frequency content on an ECT device output is analyzed. The ECT electrode-body impedance under low-current conditions is measured with an impedance analyzer. A framework for ECT modeling under quasi-static conditions based on a single device-specific frequency (e.g., 1 kHz) is proposed.
resultsImpedance using ECT electrodes under low-current is frequency dependent and subject specific, and can be approximated at >100 Hz with a subject-specific lumped parameter circuit model but at <100 Hz increased non-linearly. The ECT device uses a 2 μA 800 Hz test signal and reports a static impedance that approximate 1 kHz impedance. Combined with prior evidence suggesting that conductivity does not vary significantly across ECT output frequencies at high-currents (800-900 mA), we update the adaptive pipeline for ECT modeling centered at 1 kHz frequency. Based on individual MRI and adaptive skin properties, models match static impedance (at 2 μA) and dynamic impedance (at 900 mA) of four ECT subjects.
conclusionsBy considering ECT modeling at a single representative frequency, ECT adaptive and non-adaptive modeling can be rationalized under a quasi-static pipeline.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.