Evidence map›Paper›PMID 36933327›Full record

ArticleJournal of biomechanics2023

Linear viscoelasticity of human sclera and posterior ocular tissues during tensile creep.

Dooseop Song, Seongjin Lim, Joseph Park, Joseph L Demer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dooseop SongDepartment of Mechanical Engineering, University of California, Los Angeles, United States; Department of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, United States.
Seongjin LimDepartment of Mechanical Engineering, University of California, Los Angeles, United States; Department of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, United States.
Joseph ParkDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, United States.
Joseph L DemerDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, United States; Department of Bioengineering, University of California, Los Angeles, United States; Department of Neurology, University of California, Los Angeles, United States. Electronic address: jld@jsei.ucla.edu.
University of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERYR01EY008313 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH Louis DEMER · 1991 to 2026
$15.0M
SEARCH FOR NEW GENES IN FAMILIES WITH EPISODIC VERTIGO AND ATAXIAP50DC005224 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BALOH, ROBERT WILLIAM · 2002 to 2006
$7.5M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY008313NIDCD NIH HHS P50 DC005224
6 · The paper itself

Abstract

purposeDespite presumed relevance to ocular diseases, the viscoelastic properties of the posterior human eye have not been evaluated in detail. We performed creep testing to characterize the viscoelastic properties of ocular regions, including the sclera, optic nerve (ON) and ON sheath.

methodsWe tested 10 pairs of postmortem human eyes of average age 77 ± 17 years, consisting of 5 males and 5 females. Except for the ON that was tested in native shape, tissues were trimmed into rectangles. With physiologic temperature and constant wetting, tissues were rapidly loaded to tensile stress that was maintained by servo feedback as length was monitored for 1,500 sec. Relaxation modulus was computed using Prony series, and Deborah numbers estimated for times scales of physiological eye movements.

resultsCorrelation between creep rate and applied stress level was negligible for all tissues, permitting description as linear viscoelastic materials characterized by lumped parameter compliance equations for limiting behaviors. The ON was the most compliant, and anterior sclera least compliant, with similar intermediate values for posterior sclera and ON sheath. Sensitivity analysis demonstrated that linear behavior eventually become dominant after long time. For the range of typical pursuit tracking, all tissues exhibit Debora numbers less than 75, and should be regarded as viscoelastic. With a 6.7 Deborah number, this is especially so for the ON during pursuit and convergence.

conclusionsPosterior ocular tissues exhibit creep consistent with linear viscoelasticity necessary for describing biomechanical behavior of the ON, its sheath, and sclera during physiological eye movements and eccentric ocular fixations. Running Head: Tensile Creep of Human Ocular Tissues.

Indexed as

ScleraAgedAged, 80 and overBiomechanical PhenomenaComplianceElasticityFemaleHumansMaleMiddle AgedCreepDeborah numberOptic nerveOptic nerve sheathScleraViscoelasticity

Identifiers

PMID36933327
PMCPMC11407690
OpenAlexW4323922961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.