ArticleDevelopmental cognitive neuroscience2023
Developmental brain changes during puberty and associations with mental health problems.
Article in Developmental cognitive neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review.Biological psychiatry · 2024Pooled it
- Synaptic Actions of Estradiol in the Brain's Reward System: Linking Mechanisms to Behavior and Disease.Biological psychiatry global open science · 2026Review
- Pubertal timing predicts resting-state functional connectivity of cortical networks.Developmental cognitive neuroscience · 2026Article
- Contextualizing the adolescent social brain: Links to social health using data from the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Article
- Comparative Trends in the Burden of Depressive Disorders in China and Globally, 1990-2021: Evidence From the Global Burden of Disease 2021.Alpha psychiatry · 2026Article
- Does Parental Presence Influence Child Performance on an Emotional Go/No-Go Task at Age 9.5? Exploring the Role of Puberty and Early Environmental Quality.Developmental science · 2026Article
- Precocious Puberty and Risk of Psychiatric Disorders: A Nationwide Cohort Study Using Prospective Registry Data.The Journal of clinical endocrinology and metabolism · 2026Article
- Predicting developmental norms from baseline cortical thickness in longitudinal studies.Biology of sex differences · 2026Article
- Longitudinal changes in T1w/T2w estimates of cortical myelin with age and pubertal timing.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Synchrony between brain age and internalising and externalising symptoms across adolescence.medRxiv : the preprint server for health sciences · 2026Article
- Associations Between Screen Time, Sleep, and Executive Function in School-Aged Children and Adolescents: The Moderating Role of Digital Content and Age.Journal of clinical medicine · 2025Article
- Risk of Cognitive Decline in Women with Parkinson's Disease Is Reduced by Early Age at Menarche.Neurology international · 2025Article
- Effects of exposure to insecticides on sleep and neurobehavioural functioning in puberty and adolescence: a scoping review.Arhiv za higijenu rada i toksikologiju · 2025Article
- Current challenges and future directions for brain age prediction in children and adolescents.Nature communications · 2025Review
- Assessing neurocognitive maturation in early adolescence based on baby and adult functional brain landscapes.Developmental cognitive neuroscience · 2025Article
- Associations between parental psychological control and negative emotions in early adolescents: a moderated mediation model.Frontiers in psychology · 2025Article
- Interactive effects of social media use and puberty on resting-state cortical activity and mental health symptoms.Developmental cognitive neuroscience · 2025Article
- The association between spinal health and visual function in a pediatric population: insights from large-scale health examinations.Frontiers in public health · 2025Article
- Assessing neurocognitive maturation in early adolescence based on baby and adult functional brain landscapes.bioRxiv : the preprint server for biology · 2024Article
- Menarche, pubertal timing and the brain: female-specific patterns of brain maturation beyond age-related development.Biology of sex differences · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur understanding of the mechanisms relating pubertal timing to mental health problems via brain development remains rudimentary.
methodLongitudinal data was sourced from ∼11,500 children from the Adolescent Brain Cognitive Development (ABCD) Study (age 9-13years). We built models of "brain age" and "puberty age" as indices of brain and pubertal development. Residuals from these models were used to index individual differences in brain development and pubertal timing, respectively. Mixed-effects models were used to investigate associations between pubertal timing and regional and global brain development. Mediation models were used to investigate the indirect effect of pubertal timing on mental health problems via brain development.
resultsEarlier pubertal timing was associated with accelerated brain development, particularly of subcortical and frontal regions in females and subcortical regions in males. While earlier pubertal timing was associated with elevated mental health problems in both sexes, brain age did not predict mental health problems, nor did it mediate associations between pubertal timing and mental health problems.
conclusionThis study highlights the importance of pubertal timing as a marker associated with brain maturation and mental health problems.
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