Evidence map›Paper›PMID 36933218›Full record

ArticleCell reports2023

Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1.

Xiaojing Cui, Cuiping Zhang, Fang Wang, Xinghui Zhao, Shuxia Wang, Jinpeng Liu, Daheng He, Chi Wang, Feng-Chun Yang, Sheng Tong and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. TSP-1, TSP-2, and TSP-5 demonstrate sexual dimorphism in intimal hyperplasia in rats and mice.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  2. Review
  3. TheNon-coding RNA · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaojing CuiDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536 USA.
Cuiping ZhangDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536 USA.
Fang WangDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536 USA.
Xinghui ZhaoDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536 USA.
Shuxia WangDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536 USA.
Jinpeng LiuDivision of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536 USA.
Daheng HeDivision of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536 USA.
Chi WangDivision of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536 USA.
Feng-Chun YangDepartment of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Sheng TongDepartment of Bioengineering, University of Kentucky, Lexington, KY 40536, USA.
Ying LiangDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536 USA. Electronic address: ying.liang@uky.edu.
University of Kentucky · USThe University of Texas Health Science Center at San Antonio · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
Latexin function in the maintenance and regeneration of the hematopoietic systemR01HL124015 · NHLBI · UNIVERSITY OF KENTUCKY · PI LIANG, YING · 2016 to 2024
$3.6M
Role of SMPDL3B in obesity-associated non-alcoholic fatty liver diseaseR01DK131786 · NIDDK · UNIVERSITY OF KENTUCKY · PI Shuxia Wang · 2022 to 2026
$2.5M
Thrombospondin 1 in obesity associated inflammation and insulin resistanceR01DK098176 · NIDDK · UNIVERSITY OF KENTUCKY · PI WANG, SHUXIA · 2014 to 2017
$1.2M
Latexin in human hematopoietic stem cell expansionR21HL140213 · NHLBI · UNIVERSITY OF KENTUCKY · PI LIANG, YING · 2017 to 2018
$230k
NCI NIH HHS P30 CA177558NHLBI NIH HHS R01 HL124015NHLBI NIH HHS R21 HL140213NIDDK NIH HHS R01 DK098176NIDDK NIH HHS R01 DK131786
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate to all blood cell types. HSCs and their differentiated progeny show sex/gender differences. The fundamental mechanisms remain largely unexplored. We previously reported that latexin (Lxn) deletion increased HSC survival and repopulation capacity in female mice. Here, we find no differences in HSC function and hematopoiesis in Lxn knockout (Lxn

Indexed as

MicroRNAsThrombospondin 1AnimalsFemaleHematopoiesisMaleMiceNerve Tissue ProteinsSex CharacteristicsSex Factorslatexin protein, mouseMicroRNAsNerve Tissue ProteinsThrombospondin 1CP: Developmental biologygender differencehematopoiesishematopoietic stem celllatexinmicroRNA98-3psex dimorphismThbs1

Identifiers

PMID36933218
PMCPMC10160986
OpenAlexW4327558528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.