ArticleJournal of animal science2023
Convergent changes in melanocortin receptor 1 gene are associated with black-headed coat color in sheep.
Article in Journal of animal science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Assessment of a Reduced SNP Panel Targeting Prolificacy and Coat Color Genes in Brazilian Sheep Breeds.Animals : an open access journal from MDPI · 2026Article
- Whole-genome resequencing revealed genetic diversity and the haplotype containing MC1R associated with black coat color in Liangshan sheep.BMC genomics · 2026Article
- Genome-based analysis of the genetic pattern of black sheep in Qira sheep.BMC genomics · 2025Article
- Skin transcriptomic and selection signature analyses identifyFrontiers in genetics · 2025Article
- Transcriptomic and Metabolomic Analyses Reveal Molecular Regulatory Networks for Pigmentation Deposition in Sheep.International journal of molecular sciences · 2024Article
- Whole-Genome Sequencing for Identifying Candidate Genes Related to the Special Phenotypes of the Taihu Dianzi Pigeon.Animals : an open access journal from MDPI · 2024Article
- Genome-wide detection of selection signatures in Jianli pigs reveals novel cis-regulatory haplotype in EDNRB associated with two-end black coat color.BMC genomics · 2024Article
- The Hoof Color of Australian White Sheep Is Associated with Genetic Variation of theAnimals : an open access journal from MDPI · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
As one of the most obvious phenotypic traits, the coat color of sheep is an ideal model to study the genetic mechanisms underlying coat color varieties of mammals. One distinguishable coat color is the black-headed type, such as the famous black-headed Dorper sheep from Africa and Bayinbuluke sheep from Asia. In this study, we compared the genome sequences of black-headed and all-white sheep to identify causative genes for the black-headed sheep, including black-headed Dorper vs. white-headed Dorper, as well as Bayinbuluke (black-headed) vs. Small-tailed Han (all-white). The most differentiating region between black-headed sheep and all-white sheep was found to harbor a haplotype covering melanocortin receptor 1 (MC1R) gene. The share of this haplotype by the black-headed sheep from Africa and Asia suggested that the convergent change in the MC1R region is likely to determine this unique coat color. Two missense mutations (g. 14251947T > A and g. 14252090G > A) within this haplotype of MC1R gene were found. We further analyzed whole genome sequence data of 460 worldwide sheep with diverse coat colors and confirmed the association between the MC1R haplotype with pigmentation variations. Our study provides novel insights into coat color genetics in sheep and expands our knowledge of the link between MC1R gene and varying pigmentation patterns in sheep.
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