Evidence map›Paper›PMID 36933030›Full record

ArticleJournal of neurology2023

Abnormal thalamic functional connectivity correlates with cardiorespiratory fitness and physical activity in progressive multiple sclerosis.

Francesco Romanò, Robert W Motl, Paola Valsasina, Maria Pia Amato, Giampaolo Brichetto, Nicolò Bruschi, Jeremy Chataway, Nancy D Chiaravalloti, Gary Cutter, Ulrik Dalgas and 12 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03679468 (Improving Cognition in People With Progressive Multiple Sclerosis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03679468 nacompletednot on this map

Improving Cognition in People With Progressive Multiple Sclerosis: A Multi-Arm, Randomized, Blinded, Sham-Controlled Trial of Cognitive Rehabilitation and Aerobic Exercise.

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2019 to 2023Enrolled309ConditionsMultiple Sclerosis, Primary Progressive, Cognitive ImpairmentArmsCognitive Rehabilitation, Sham Exercise, Sham Cognitive Rehabilitation, Aerobic Exercise
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 6 countries.

Francesco RomanòNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Robert W MotlDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Paola ValsasinaNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Maria Pia AmatoSection Neurosciences, Department NEUROFARBA, University of Florence, Florence, Italy.
Giampaolo BrichettoScientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Via Operai 40, 16149, Genoa, Italy.
Nicolò BruschiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Jeremy ChatawayFaculty of Brain Sciences, Queen Square MS Centre, UCL Queen Square Institute of Neurology, UCL, London, UK.ORCID http://orcid.org/0000-0001-7286-6901
Nancy D ChiaravallotiKessler Foundation, West Orange, NJ, USA.
Gary CutterDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Ulrik DalgasExercise Biology, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000, Aarhus, Denmark.
John DeLucaKessler Foundation, West Orange, NJ, USA.
Rachel FarrellFaculty of Brain Sciences, Queen Square MS Centre, UCL Queen Square Institute of Neurology, UCL, London, UK.
Peter FeysFaculty of Rehabilitation Sciences, REVAL, Hasselt University, Diepenbeek, Belgium.
Jennifer FreemanFaculty of Health, School of Health Professions, University of Plymouth, Devon, UK.
Matilde IngleseDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Cecilia MezaDepartment of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, M5R 3B6, Canada.
Amber SalterSection on Statistical Planning and Analysis, Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA.
Brian M SandroffKessler Foundation, West Orange, NJ, USA.
Anthony FeinsteinDepartment of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, M5R 3B6, Canada.
Maria A RoccaNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Massimo FilippiNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy. filippi.massimo@hsr.it.ORCID http://orcid.org/0000-0002-5485-0479
CogEx Research Team
Vita-Salute San Raffaele University · ITRutgers, The State University of New Jersey · USSunnybrook Health Science Centre · CAAarhus University · DKAssociazione Italiana Sclerosi Multipla · ITDon Carlo Gnocchi Foundation · ITHasselt University · BENational Hospital for Neurology and Neurosurgery · GBNational Institute for Health Research · GBOspedale Policlinico San Martino · ITSouthwestern Medical CenterUniversity of Alabama at Birmingham · USUniversity of Genoa · ITUniversity of Illinois Chicago · USUniversity of Plymouth · GB

Funding

Multiple Sclerosis Society of Canada EGID3185
6 · The paper itself

Abstract

backgroundAltered thalamic volumes and resting state (RS) functional connectivity (FC) might be associated with physical activity (PA) and cardiorespiratory fitness (CRF) in people with progressive multiple sclerosis (PMS).

objectivesTo assess thalamic structural and functional alterations and investigate their correlations with PA/CRF levels in people with PMS.

methodsSeven-day accelerometry and cardiopulmonary exercise testing were used to assess PA/CRF levels in 91 persons with PMS. They underwent 3.0 T structural and RS fMRI acquisition with 37 age/sex-matched healthy controls (HC). Between-group comparisons of MRI measures and their correlations with PA/CRF variables were assessed.

resultsPMS people had lower volumes compared to HC (all p < 0.001). At corrected threshold, PMS showed decreased intra- and inter-thalamic RS FC, and increased RS FC between the thalamus and the hippocampus, bilaterally. At uncorrected threshold, decreased thalamic RS FC with caudate nucleus, cerebellum and anterior cingulate cortex (ACC), as well as increased thalamic RS FC with occipital regions, were also detected. Lower CRF, measured as peak oxygen consumption (VO DISCUSSION: People with PMS showed widespread brain atrophy, as well as pronounced intra-thalamic and thalamo-hippocampal RS FC abnormalities. White matter atrophy correlated with CRF, while increased thalamo-hippocampal RS FC was associated to worse PA levels. Thalamic RS FC might be used to monitor physical impairment and efficacy of rehabilitative and disease-modifying treatments in future studies.

Indexed as

Cardiorespiratory FitnessMultiple SclerosisMultiple Sclerosis, Chronic ProgressiveAtrophyHumansMagnetic Resonance ImagingThalamusFitnessFunctional connectivityMRIMultiple sclerosisPhysical activityThalamus

Identifiers

PMID36933030
OpenAlexW4327811332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.