SynthesisBMC oral health2023
Cleaning efficacy of EDDY versus ultrasonically-activated irrigation in root canals: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Effectiveness of the GentleWave system in root canal disinfection: a systematic review.BMC oral health · 2026Pooled it
- Mapping risk of bias criteria in systematic reviews of in vitro endodontic studies: an umbrella review.Evidence-based dentistry · 2025Pooled it
- Pooled it
- Comparative evaluation of irrigant activation devices for removal of calcium hydroxide from artificial isthmuses connecting curved canals in 3D-printed resin molar models.BMC oral health · 2026Article
- Effects of Sodium Hypochlorite Concentration and Final Irrigation Protocol on Residual Filling Material in Retreated Oval Root Canals Obturated with a Calcium Silicate-Based Sealer: A Scanning Electron Microscopy Study.Medicina (Kaunas, Lithuania) · 2026Article
- Management of Failed Apexification Associated with Internal Root Resorption and Apical Calcification: A 56-Month Case Report.Dentistry journal · 2026Article
- Clinical Outcomes of Plasma-Assisted Saline Irrigation in Nonsurgical Root Canal Treatment: A Preliminary Retrospective Cohort Study.Biomedicines · 2026Article
- Comparison of diode laser and sonic activation in the removal of root canal filling material from curved canals: an in-vitro study.BMC oral health · 2026Article
- Comparative Evaluation of Polymeric and Metal Ultrasonic Tips for the Removal of Calcium Hydroxide From Root Canals.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Evaluation of the effects of different irrigation activation techniques on the surface roughness of dentin and blood clot in regenerative endodontic models.Lasers in medical science · 2026Article
- CLSM-Guided Imaging to Visualize the Depth of Effective Disinfection in Endodontics.Antibiotics (Basel, Switzerland) · 2025Article
- Micro-computed tomography evaluation of sonically or ultrasonically activated irrigation on the removal of tricalcium silicate-based intracanal dressing.Journal of conservative dentistry and endodontics · 2025Article
- Efficacy of high-frequency sonic irrigation on removing debris from root canal isthmus: anPeerJ · 2025Article
- Debris and Smear Layer Removal in Curved Root Canals: A Comparative Study of Ultrasonic and Sonic Irrigant Activation Techniques.Dentistry journal · 2024Article
- Article
- Efficacy of Different Irrigant Activation Systems on Debris and Smear Layer Removal: A Scanning Electron Microscopy Evaluation.International journal of dentistry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUltrasonically-activated irrigation (UAI) is effective in root canal irrigation but may damage canal walls. EDDY is a sonic activation system with flexible working tips that cause no harm to dentinal walls. This review explores the intracanal cleaning efficacy of EDDY compared with UAI in vitro.
methodsThe systematic review was registered in the PROSPERO database (CRD42021235826). A literature search was conducted in six electronic databases. In vitro studies that compared the removal of smear layer, debris, soft tissue or microbes in root canals between EDDY and UAI were included. Data extraction and quality assessment were performed. Meta-analyses were conducted on smear layer removal and debris elimination with the standardized mean difference (SMD). Heterogeneity was measured using the I
results19 articles were included in this systematic review and 7 articles were included in meta-analyses. Meta-analyses on smear layer removal showed unimportant differences between EDDY and UAI at any canal third (coronal [SMD = 0.08, 95% confidence interval (95%CI): -0.29 to 0.45; p = 0.44, I
conclusionsLimited evidence indicated that EDDY was comparable to UAI in removing smear layer, debris, soft tissue and microbes ex vivo. Considering UAI may damage canal walls, EDDY might be a substitute for UAI in irrigation activation. But more randomized clinical trials are required to explore the clinical extrapolation of the results in this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.