Evidence map›Paper›PMID 36932276›Full record

ArticleCell biology and toxicology2023

Assay conditions for estimating differences in base excision repair activity with Fpg-modified comet assay.

Congying Zheng, Andrew Collins, Gunnar Brunborg, Frederik-Jan van Schooten, Anne Lene Nordengen, Sergey Shaposhnikov, Roger Godschalk

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Congying ZhengDepartment of Pharmacology and Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200, Maastricht, Netherlands.
Andrew CollinsNorgenotech AS, 64/66, Ullernchassern, Oslo, Norway.
Gunnar BrunborgNorgenotech AS, 64/66, Ullernchassern, Oslo, Norway.
Frederik-Jan van SchootenDepartment of Pharmacology and Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200, Maastricht, Netherlands.
Anne Lene NordengenNorgenotech AS, 64/66, Ullernchassern, Oslo, Norway.
Sergey ShaposhnikovNorgenotech AS, 64/66, Ullernchassern, Oslo, Norway.
Roger GodschalkDepartment of Pharmacology and Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200, Maastricht, Netherlands. r.godschalk@maastrichtuniversity.nl.
Maastricht University · NLCancer Registry of Norway · NOUniversity of Agder · NO

Funding

the European Un'on's Horizon 2020 research and innovation training networks (ITN, aDDress, Marie-Skłodowska-Curie grant agreement ) 812829
6 · The paper itself

Abstract

DNA repair is an essential agent in cancer development, progression, prognosis, and response to therapy. We have adapted a cellular repair assay based on the formamidopyrimidine DNA glycosylase (Fpg)-modified comet assay to assess DNA repair kinetics. The removal of oxidized nucleobases over time (0-480 min) was analyzed in peripheral blood mononuclear cells (PBMCs) and 8 cell lines. DNA damage was induced by exposure to either Ro19-8022 plus visible light or potassium bromate (KBrO

Indexed as

DNA RepairLeukocytes, MononuclearComet AssayDNA DamageDNA-Formamidopyrimidine GlycosylaseDNA-Formamidopyrimidine GlycosylaseAntioxidant statusCellular repairComet assayDNA repair capacityFpg

Identifiers

PMID36932276
PMCPMC10693524
OpenAlexW4327724195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.