Evidence map›Paper›PMID 36932270›Full record

ArticleJournal of autism and developmental disorders2024

No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children.

Seppo P Ahlfors, Steven Graham, Hari Bharadwaj, Fahimeh Mamashli, Sheraz Khan, Robert M Joseph, Ainsley Losh, Stephanie Pawlyszyn, Nicole M McGuiggan, Mark Vangel and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Seppo P AhlforsAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA. sahlfors@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-7674-6931
Steven GrahamDepartment of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Hari BharadwajDepartment of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Fahimeh MamashliAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Sheraz KhanAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Robert M JosephDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Ainsley LoshDepartment of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Stephanie PawlyszynDepartment of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Nicole M McGuigganDepartment of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Mark VangelAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Matti S HämäläinenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Tal KenetAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Harvard University · USBoston University · USMassachusetts General Hospital · US

Funding

Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2020 to 2026
$10.9M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Scalable Software for Distributed Processing and Visualization of Multi-Site MEG/EEG DatasetsR01NS104585 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATTI HAMALAINEN · 2018 to 2026
$4.3M
Testing the Bottom-Up vs Top-Down Imbalance Hypothesis of ASDR01MH117998 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI KENET, TAL · 2018 to 2023
$4.0M
Functional connectivity substrates of social and non-social deficits in ASDR01HD073254 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI KENET, TAL · 2013 to 2017
$3.4M
Non-invasive measures of multisensory cortical feedforward and feedback influencesR01DC016765 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHLFORS, SEPPO PENTTI, AHVENINEN, JYRKI · 2018 to 2022
$2.7M
Identifying the neural structures and dynamics that regulate phonological structureR01DC015455 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHLFORS, SEPPO PENTTI, GOW, DAVID W · 2017 to 2021
$2.7M
Translating MEG-based biomarkers to EEG-based outcome measures for Autism Spectrum DisordersR21MH116517 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI KENET, TAL · 2018 to 2019
$463k
High Temporal Resolution Study of Resting-State Cerebro-Cerebellar Functional Connectivity in ASDR21MH127523 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI KENET, TAL · 2022 to 2023
$462k
national institute of child health and human development R01HD073254NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41EB015896NIBIB NIH HHS P41 EB030006NIBIB NIH HHS P41EB030006NICHD NIH HHS R01 HD073254NIDCD NIH HHS R01 DC015455NIDCD NIH HHS R01DC015455NIDCD NIH HHS R01 DC016765NIDCD NIH HHS R01DC016765NIMH NIH HHS R01 MH117998NIMH NIH HHS R01MH117998NIMH NIH HHS R21 MH116517NIMH NIH HHS R21MH116517NIMH NIH HHS R21 MH127523NINDS NIH HHS R01 NS104585NINDS NIH HHS R01NS104585simons foundation SFARI 239395
6 · The paper itself

Abstract

Auditory steady-state response (ASSR) has been studied as a potential biomarker for abnormal auditory sensory processing in autism spectrum disorder (ASD), with mixed results. Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically developing (TD) individuals at twice the steady-state stimulation frequency, we examined ASSR at 25 and 50 as well as 43 and 86 Hz in response to 25-Hz and 43-Hz auditory stimuli, respectively, using magnetoencephalography. Data were recorded from 22 ASD and 31 TD children, ages 6-17 years. ITC measures showed prominent ASSRs at the stimulation and double frequencies, without significant group differences. These results do not support ASSR as a robust ASD biomarker of abnormal auditory processing in ASD. Furthermore, the previously observed atypical double-frequency somatosensory response in ASD did not generalize to the auditory modality. Thus, the hypothesis about modality-independent abnormal local connectivity in ASD was not supported.

Indexed as

Acoustic StimulationAuditory PerceptionAutism Spectrum DisorderEvoked Potentials, AuditoryMagnetoencephalographyAdolescentChildFemaleHumansMaleAuditory Steady-State Response (ASSR)Autism Spectrum Disorder (ASD)Gamma-bandInter-Trial Coherence (ITC)Magnetoencephalography (MEG)

Identifiers

PMID36932270
PMCPMC11463296
OpenAlexW4327724282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.