ArticleJournal of cardiovascular translational research2023
Effect of Beta Blockers on the Hemodynamics and Thrombotic Risk of Coronary Artery Aneurysms in Kawasaki Disease.
Article in Journal of cardiovascular translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Cytoprotection as a Unifying Strategy for Hemorrhage and Thrombosis: The Role of BPC 157 and Related Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2026Review
- A Simulation-Based Comparison of Human, Porcine and Ovine Pulmonary Artery Hemodynamics. Evaluating the Suitability of Large Animal Models for Endopulmonary Device Evaluation from a Hemodynamics Point of View.Cardiovascular engineering and technology · 2025Article
- Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening.Science advances · 2025Article
- Sensitivity of Left Atrial Flow Dynamics to Echocardiographic and Computed Tomography Data.Journal of cardiovascular translational research · 2025Article
- Evaluating the Cavitary Lung Lesions on CT Scan of COVID-19 Patients: A Retrospective Study.Journal of community hospital internal medicine perspectives · 2024Article
- Evaluation ofMedical journal of the Islamic Republic of Iran · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to simulate beta blockers' (BB) effects on coronary artery aneurysms' (CAA) hemodynamics and thrombotic risk in Kawasaki disease (KD). BB are recommended in cases of large aneurysms due to their anti-ischemic effect. Coronary blood flow (CBF) was simulated in KD patient-specific CAA models using computational fluid dynamics. Hemodynamic indices that correlate with thrombotic risk were calculated following two possible responses to BB: (1) preserved coronary flow (third BB generation) and (2) reduction in coronary flow (first and second BB generations) at reduced heart rate. Following CBF reduction scenario, mean TAWSS and HOLMES significantly decreased compared to normal conditions, leading to a potential increase in thrombotic risk. Preserved CBF at lower heart rates, mimicking the response to vasodilating BBs, does not significantly affect local CAA hemodynamics compared with baseline, while achieving the desired anti-ischemic effects. Different BB generations lead to different hemodynamic responses in CAA.
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Registered trials
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