Evidence map›Paper›PMID 36932231›Full record

ArticleActa pharmacologica Sinica2023

Functional characterization and in vitro pharmacological rescue of KCNQ2 pore mutations associated with epileptic encephalopathy.

Gui-Mei Yang, Fu-Yun Tian, Yan-Wen Shen, Chuan-Yan Yang, Hui Yuan, Ping Li, Zhao-Bing Gao

Open access · hybridAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

  1. Patient outcomes in KCNQ2 developmental and epileptic encephalopathy.Developmental medicine and child neurology · 2026
    Review
  2. Article
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  12. Loss-of-function of the Zinc Finger Homeobox 4 (medRxiv : the preprint server for health sciences · 2024
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Gui-Mei Yang *School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.
Fu-Yun Tian *Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. tianfuyun@zidd.ac.cn.
Yan-Wen Shen *Department of Pediatrics, The First Medical Center of PLA General Hospital, Beijing, 100853, China.
Chuan-Yan YangZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.
Hui YuanSchool of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.
Ping LiSchool of Pharmacy, Zunyi Medical University, Zunyi, 563000, China. lipingt@simm.ac.cn.
Zhao-Bing GaoSchool of Pharmacy, Zunyi Medical University, Zunyi, 563000, China. zbgao@simm.ac.cn.
Zunyi Medical University · CNChina Pharmaceutical University · CNChinese Academy of Sciences · CNChinese PLA General Hospital · CNShanghai Institute of Materia Medica · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the KCNQ2 gene encoding K

Indexed as

Brain DiseasesKCNQ2 Potassium ChannelAnimalsCarbamatesCHO CellsCricetinaeCricetulusKCNQ3 Potassium ChannelMutationPropylaminesCarbamatesKCNQ2 Potassium ChannelKCNQ3 Potassium ChannelPropylaminespynegabinedevelopmental and epileptic encephalopathy (DEE)electrophysiologyKCNQ2 pore mutationspynegabine (HN37)retigabine (RTG)XEN1101

Identifiers

PMID36932231
PMCPMC10374643
OpenAlexW4327811576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.