Evidence map›Paper›PMID 36932196›Full record

ArticleCancer gene therapy2023

MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo.

Yichao Liang, Di Wu, Qiao Qu, Zhilong Li, Hongzhuan Yin

Abstract read
PubMed Publisher
In one paragraph

Article in Cancer gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yichao LiangDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.
Di WuDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.
Qiao QuDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.
Zhilong LiDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.
Hongzhuan YinDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China. hzyin@cmu.edu.cn.ORCID 0000-0002-8029-0911
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MORC family CW-type zinc finger 4 (MORC4) possessing nuclear matrix binding domains has been observed to be involved in multiple cancer development. By digging three gene expression omnibus (GEO) gene microarrays (GSE110223, GSE110224 and GSE24514), we found that MORC4 was overexpressed in colorectal cancer (CRC) samples (log

Indexed as

Colorectal NeoplasmsTranscription FactorsCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent KinasesGene Expression Regulation, NeoplasticHumansNuclear ProteinsPolycomb Repressive Complex 1Ubiquitin-Protein LigasesCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent KinasesHECW2 protein, humanMORC4 protein, humanNuclear ProteinsPCGF1 protein, humanPolycomb Repressive Complex 1Transcription FactorsUbiquitin-Protein Ligases

Identifiers

PMID36932196
OpenAlexW4327743726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.