ArticleScientific reports2023
Systematic analysis of prophage elements in actinobacterial genomes reveals a remarkable phylogenetic diversity.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication.Angewandte Chemie (International ed. in English) · 2026Article
- Genus-wide Homologous Recombination of Tail Fibers Maintains Tailocin Diversity in Pectobacterium.Genome biology and evolution · 2026Article
- A new-engineered integrative tool to target the terminal compartment of the Streptomyces chromosome.Applied microbiology and biotechnology · 2026Article
- Prophage: agent provocateur?Archives of microbiology · 2026Review
- Abundance-activity decoupling in sulfur-cycling bacteria reflects viral infection types in meromictic lakes.The ISME journal · 2026Article
- Bacterial peptide deformylase inhibitors induce prophages in competitors.bioRxiv : the preprint server for biology · 2025Article
- Pangenomics to understand prophage dynamics in theMicrobial genomics · 2025Article
- Unveiling Hidden Allies: In Silico Discovery of Prophages inAntibiotics (Basel, Switzerland) · 2024Article
- Chromosome architecture as a determinant for biosynthetic diversity inMicrobial genomics · 2024Article
- Prophage induction can facilitate the in vitro dispersal of multicellular Streptomyces structures.PLoS biology · 2024Article
- Genomic and taxonomic evaluation of 38 Treponema prophage sequences.BMC genomics · 2024Article
- Tailless and filamentous prophages are predominant in marine Vibrio.The ISME journal · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Actinobacteria represent one of the largest bacterial phyla harboring many species of high medical, biotechnological and ecological relevance. Prophage elements are major contributors to bacterial genome diversity and were shown to significantly shape bacterial fitness and host-microbe interactions. In this study, we performed a systematic analysis of prophage elements in 2406 complete actinobacterial genomes. Overall, 2106 prophage elements were predicted to be present in about 50% (1172/2406) of the analyzed datasets. Interestingly, these identified sequences compose a high prevalence of cryptic prophage elements, indicating genetic decay and domestication. Analysis of the sequence relationship of predicted prophages with known actinobacteriophage genomes revealed an exceptional high phylogenetic diversity of prophage elements. As a trend, we observed a higher prevalence of prophage elements in vicinity to the terminus. Analysis of the prophage-encoded gene functions revealed that prophage sequences significantly contribute to the bacterial antiviral immune system, but no biosynthetic gene clusters involved in the synthesis of known antiphage molecules were identified in prophage genomes. Overall, the current study highlights the remarkable diversity of prophages in actinobacterial genomes, with highly divergent prophages in actinobacterial genomes and thus provides an important basis for further investigation of phage-host interactions in this important bacterial phylum.
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