Evidence map›Paper›PMID 36932117›Full record

ArticleScientific reports2023

Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years.

Joyce John, Alys R Clark, Haribalan Kumar, Alain C Vandal, Kelly S Burrowes, Margaret L Wilsher, David G Milne, Brian Bartholmai, David L Levin, Ronald Karwoski and 1 more

Open access · goldFull text read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. A Quantitative Imaging Measure of Progressive Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2025
    Article
  4. Article
  5. Article
  6. Quantitative Computed Tomography in Idiopathic Pulmonary Fibrosis: Is It Time to Act?American journal of respiratory and critical care medicine · 2024
    Article
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Joyce JohnAuckland Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Alys R ClarkAuckland Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Haribalan KumarAuckland Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Alain C VandalDepartment of Statistics, The University of Auckland, Auckland, New Zealand.
Kelly S BurrowesAuckland Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Margaret L WilsherRespiratory Services, Auckland City Hospital, Auckland, New Zealand.
David G MilneRadiology, Auckland City Hospital, Auckland, New Zealand.
Brian BartholmaiRadiology, Mayo Clinic, Rochester, MN, USA.
David L LevinRadiology, Mayo Clinic, Rochester, MN, USA.
Ronald KarwoskiRadiology, Mayo Clinic, Rochester, MN, USA.
Merryn H TawhaiAuckland Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand. m.tawhai@auckland.ac.nz.
University of Auckland · NZMayo Clinic in Arizona · USAuckland City Hospital · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is characterised by progressive fibrosing interstitial pneumonia with an associated irreversible decline in lung function and quality of life. IPF prevalence increases with age, appearing most frequently in patients aged > 50 years. Pulmonary vessel-like volume (PVV) has been found to be an independent predictor of mortality in IPF and other interstitial lung diseases, however its estimation can be impacted by artefacts associated with image segmentation methods and can be confounded by adjacent fibrosis. This study compares PVV in IPF patients (N = 21) with PVV from a healthy cohort aged > 50 years (N = 59). The analysis includes a connected graph-based approach that aims to minimise artefacts contributing to calculation of PVV. We show that despite a relatively low extent of fibrosis in the IPF cohort (20% of the lung volume), PVV is 2-3 times higher than in controls. This suggests that a standardised method to calculate PVV that accounts for tree connectivity could provide a promising tool to provide early diagnostic or prognostic information in IPF patients and other interstitial lung disease.

Indexed as

Idiopathic Pulmonary FibrosisLung Diseases, InterstitialFibrosisHumansMiddle AgedPrognosisQuality of Life

Identifiers

PMID36932117
PMCPMC10023743
OpenAlexW4327742363

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read28
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.