ArticleNature communications2023
The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Cerebellar Transcranial Alternating Current Stimulation in the Theta Band Prevents Recall of the Initial Fear Association After Extinction Training.Human brain mapping · 2026Trial
- The Timing of Attentional Distraction Matters in Facilitating Extinction of Trace Fear Memory.Experimental neurobiology · 2026Article
- Region- and cell type-specific changes in gene expression in the cerebellum after classical fear conditioning.Communications biology · 2026Article
- Predicting individual differences of fear and cognitive learning and extinction.Nature communications · 2026Article
- Magnetic resonance microscopy maps widespread effects of Alzheimer's disease on brain structures and behavior in mice.Nature neuroscience · 2026Article
- Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction.Molecular brain · 2025Article
- Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity.Nature communications · 2025Article
- Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors.Nature neuroscience · 2025Article
- Analysis of Common Genetic Variation of Anxiety Disorders in Essential Tremor.Journal of molecular neuroscience : MN · 2025Article
- Purkinje cell activity changes in cerebellar subregions during fear conditioning.Frontiers in behavioral neuroscience · 2025Article
- Investigating Cerebello-Frontal Circuits Associated with Emotional Prosody: A Double-Blind tDCS and fNIRS study.Cerebellum (London, England) · 2024Article
- Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity.bioRxiv : the preprint server for biology · 2024Article
- Memory Trace for Fear Extinction: Fragile yet Reinforceable.Neuroscience bulletin · 2024Review
- Re-examining the Mysterious Role of the Cerebellum in Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory.Molecular psychiatry · 2024Article
- Age-related changes of dopamine D1 and D2 receptors expression in parvalbumin-positive cells of the orbitofrontal and prelimbic cortices of mice.Frontiers in neuroscience · 2024Article
- Cognitive-Affective Functions of the Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain.Nature neuroscience · 2023Article
- Selection for Reduced Fear of Humans Changes Brain and Cerebellum Size in Red Junglefowl in Line with Effects of Chicken Domestication.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fear extinction is a form of inhibitory learning that suppresses the expression of aversive memories and plays a key role in the recovery of anxiety and trauma-related disorders. Here, using male mice, we identify a cerebello-thalamo-cortical pathway regulating fear extinction. The cerebellar fastigial nucleus (FN) projects to the lateral subregion of the mediodorsal thalamic nucleus (MD), which is reciprocally connected with the dorsomedial prefrontal cortex (dmPFC). The inhibition of FN inputs to MD in male mice impairs fear extinction in animals with high fear responses and increases the bursting of MD neurons, a firing pattern known to prevent extinction learning. Indeed, this MD bursting is followed by high levels of the dmPFC 4 Hz oscillations causally associated with fear responses during fear extinction, and the inhibition of FN-MD neurons increases the coherence of MD bursts and oscillations with dmPFC 4 Hz oscillations. Overall, these findings reveal a regulation of fear-related thalamo-cortical dynamics by the cerebellum and its contribution to fear extinction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.