Evidence map›Paper›PMID 36931889›Full record

ArticleMedical mycology2023

Whole-genome sequencing of Candida haemulonii species complex from Brazil and the United States: Genetic diversity and antifungal susceptibility.

Dality Keffelen de Barros Rodrigues, Shawn R Lockhart, Elizabeth L Berkow, Lalitha Gade, Lucas Xavier Bonfietti, Viviane Mazo Fávero Gimenes, Luciana Silva Ruiz, Milena Bronze Macioni, Marcia de Souza Carvalho Melhem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical mycology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Virulence Traits and Azole Resistance in KoreanJournal of fungi (Basel, Switzerland) · 2023
    Article
  6. Zoonoses (Shannon, Ireland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dality Keffelen de Barros RodriguesPrograma de Pós-graduação em Doenças Infecciosas e Parasitárias, Universidade Federal do Mato Grosso do Sul, Mato Grosso do Sul, MS, Brazil.ORCID 0000-0003-0835-0948
Shawn R LockhartMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Elizabeth L BerkowMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Lalitha GadeMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Lucas Xavier BonfiettiNúcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde, São Paulo, SP, Brazil.
Viviane Mazo Fávero GimenesLaboratório de Micologia Médica-LIM 53, Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, SP, Brazil.
Luciana Silva RuizNúcleo de Ciências Biomédicas, Instituto Adolfo Lutz, Regional Bauru, São Paulo, SP, Brazil.ORCID 0000-0001-7374-8640
Milena Bronze MacioniNúcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde, São Paulo, SP, Brazil.
Marcia de Souza Carvalho MelhemPrograma de Pós-graduação em Doenças Infecciosas e Parasitárias, Universidade Federal do Mato Grosso do Sul, Mato Grosso do Sul, MS, Brazil.

Funding

CNPq #303324/2018-0Intramural CDC HHS CC999999São Paulo Research Foundation #2017/50333-7
6 · The paper itself

Abstract

Candida haemulonii complex species can be multidrug-resistant and cause infections such as candidemia. This study determined the genetic relationship between isolates from Brazil and the United States through whole-genome sequencing and performed antifungal susceptibility testing to investigate drug resistance. Contrary to what is widely described, most isolates were susceptible to azoles. However, an atypical susceptibility profile was found in 50% of Candida pseudohaemulonii strains, including resistance to the three echinocandins. Isolates from both countries formed distinct clusters with wide genetic diversity. Isolates from three hospitals in Brazil were clonal and involved in candidemia cases, pointing to the importance of improving hospital infection control measures and molecular identification.

Indexed as

Antifungal AgentsCandidemiaAnimalsBrazilCandidaDrug Resistance, FungalGenetic VariationMicrobial Sensitivity TestsSaccharomycetalesUnited StatesAntifungal Agentscandidemiadrug resistanceechinocandinssequence analysis

Identifiers

PMID36931889
PMCPMC11321273

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.