Evidence map›Paper›PMID 36931755›Full record

Trial reportThe Journal of nutrition2023

Association of Changes in Neural Targets and Dietary Outcomes among Patients with Comorbid Obesity and Depression: Post hoc Analysis of ENGAGE-2 Mechanistic Clinical Trial.

Nan Lv, Hagar Hallihan, Lan Xiao, Leanne M Williams, Olusola A Ajilore, Jun Ma

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03841682 (Engaging Self-Regulation Targets to Understand the Mechanism of Behavior Change and Improve Mood and Weight Outcomes- Second Phase), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03841682 nacompletednot on this map

Engaging Self-Regulation Targets to Understand the Mechanism of Behavior Change and Improve Mood and Weight Outcomes- Second Phase (ENGAGE-2)

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2019 to 2021Enrolled106ConditionsObesity, DepressionArmsI-CARE2
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nan LvDepartment of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Hagar HallihanDepartment of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Lan XiaoDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Leanne M WilliamsDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Olusola A AjiloreDepartment of Psychiatry, University of Illinois Chicago, Chicago, IL, USA.
Jun MaDepartment of Medicine, University of Illinois Chicago, Chicago, IL, USA. Electronic address: maj2015@uic.edu.
University of Illinois Chicago · USStanford University · US

Funding

Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomesUH3HL132368 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MA, JUN, WILLIAMS, LEANNE · 2018 to 2019
$2.6M
Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomesUH2HL132368 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MA, JUN, WILLIAMS, LEANNE · 2015 to 2017
$2.6M
Precision Lifestyle Medicine and Translation Research (PREMIER)T32HL134634 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RACHEL CASKEY, Jun Ma · 2018 to 2026
$2.4M
The ALOHA trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary PatternR61HL155160 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MA, JUN · 2021 to 2021
$826k
NHLBI NIH HHS R61 HL155160NHLBI NIH HHS T32 HL134634NHLBI NIH HHS UH2 HL132368NHLBI NIH HHS UH3 HL132368
6 · The paper itself

Abstract

backgroundDisruptions in brain circuits that regulate cognition and emotion can hinder dietary change and weight loss among individuals with obesity and depression.

objectiveThe study aimed to investigate whether changes in brain targets in the cognitive control, negative affect, and positive affect circuits after 2-mo problem-solving therapy (PST) predict changes in dietary outcomes at 2 and 6 mo.

methodsAdults with obesity and depression from an academic health system were randomly assigned to receive PST (7-step problem-solving and behavioral activation strategies) over 2 mo or usual care. Seventy participants (mean age = 45.9 ± 11.6 y; 75.7% women, 55.7% Black, 17.1% Hispanic, 20.0% White; mean BMI = 36.5 ± 5.3 kg/m

resultsAmong intervention participants, increased left dorsal lateral prefrontal cortex (dLPFC) activity of the cognitive control circuit at 2 mo was associated with increased diet quality (β: 0.20; 95% CI: -0.02, 0.42) and decreased calories (β: -0.19; 95% CI: -0.33, -0.04), fat levels (β: -0.22; 95% CI: -0.39, -0.06), and high-sugar food intake (β: -0.18; 95% CI: -0.37, 0.01) at 6 mo. For the negative affect circuit, increased right dLPFC-amygdala connectivity at 2 mo was associated with increased diet quality (β: 0.32; 95% CI: -0.93, 1.57) and fruit and vegetable intake (β: 0.38; 95% CI: -0.75, 1.50) and decreased calories (β: -0.37; 95% CI: -1.29, 0.54), fat levels (β: -0.37; 95% CI: -1.50, 0.76), sodium concentrations (β: -0.36; 95% CI: -1.32, 0.60), and alcohol intake (β: -0.71; 95% CI: -2.10, 0.68) at 2 but not at 6 mo. The usual care group showed opposing associations. The 95% CIs of all between-group differences did not overlap the null, suggesting a significant treatment effect.

conclusionsAmong adults with obesity and depression who underwent PST compared with those under usual care, improved dLPFC-amygdala regulation of negative affective brain states predicted dietary improvements at 2 mo, whereas improvements in dLPFC-based cognitive control predicted dietary improvements at 6 mo. These findings warrant confirmatory studies. This trial was at clinicaltrials.gov as NCT03841682.

Indexed as

DepressionObesityAdultDietEnergy IntakeFemaleFruitHumansMaleMiddle Agedamygdalacognitive controldepressiondietdorsal lateral prefrontal cortexfunctional neuroimagingnegative affectobesity

Identifiers

PMID36931755
PMCPMC10196721
OpenAlexW4317754387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.