Evidence map›Paper›PMID 36931723›Full record

ArticleMolecular oncology2023

NKG2A and circulating extracellular vesicles are key regulators of natural killer cell activity in prostate cancer after prostatectomy.

Yu-Chuan Lu, Chen-Hsun Ho, Jian-Hua Hong, Ming-Chieh Kuo, Yi-An Liao, Fu-Shan Jaw, Jason Chia-Hsien Cheng, Chao-Yuan Huang, Ko-Ping Chang, Chung-Hsin Chen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 5 citations in OpenAlex.

  1. Human Group IIA Secreted Phospholipase AInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Yu-Chuan LuDepartment of Surgical Oncology, National Taiwan University Cancer Center, National Taiwan University College of Medicine, Taipei, Taiwan.
Chen-Hsun HoDivision of Urology, Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Jian-Hua HongDepartment of Urology, National Taiwan University Hospital, Taipei, Taiwan.
Ming-Chieh KuoDepartment of Urology, National Taiwan University Hospital, Yunlin Branch, National Taiwan University College of Medicine, Taipei, Taiwan.
Yi-An LiaoDepartment of Urology, National Taiwan University Hospital, Taipei, Taiwan.
Fu-Shan JawInstitute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
Jason Chia-Hsien ChengDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
Chao-Yuan HuangDepartment of Urology, National Taiwan University Hospital, Taipei, Taiwan.
Ko-Ping ChangDepartment of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Chung-Hsin ChenDepartment of Urology, National Taiwan University Hospital, Taipei, Taiwan.
Jung-An LinGraduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
An HsiaoGraduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hsiu-Ni KungGraduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0001-6979-8346
National Taiwan University · TWNational Taiwan University Hospital · TWFu Jen Catholic University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are an important regulatory factor for natural killer cell activity (NKA) in the tumor microenvironment. The relationship between circulating EVs in the peripheral blood and natural killer (NK) cells in prostate cancer (PCa) is unclear. This study aimed at investigating the key regulators in the interaction between circulating EVs and NK cells in PCa patients before and after tumor removal. NK-cell characteristics were prospectively assessed in 79 patients treated with robot-assisted laparoscopic radical prostatectomy preoperatively and postoperatively. Compared with healthy donors, the existence of prostate tumors increased the number of circulating EVs and altered ligand expression of EVs. Circulating EVs extracted from cancer patients significantly decreased NKA of NK cells compared with those extracted from healthy donors. Upon treatment with an inhibiting antibody or small interfering RNA, natural killer cell protein group 2A (NKG2A) was identified as the main NKA regulator in cancer patients for accepting the signal from circulating EVs. After surgery, NKA was increased and NKG2A expression on NK cells was significantly reduced. The expression of ligands for natural killer cell protein group 2D (NKG2D) on EVs and the level of circulation EVs both significantly increased. With the decrease in NKG2A levels on NK cells and the increase in total NKG2D ligands on circulating EVs, which was increased postoperatively, both NKG2A on NK cells and NKG2D ligands on circulating exosomes are main regulators of NKA restoration after prostatectomy.

Indexed as

Extracellular VesiclesProstatic NeoplasmsHumansKiller Cells, NaturalLigandsMaleNK Cell Lectin-Like Receptor Subfamily KProstatectomyTumor MicroenvironmentLigandsNK Cell Lectin-Like Receptor Subfamily Kcirculating EVsligand alterationsnatural killer cell activityNKG2Aprostate cancerrobotic-assisted radical prostatectomy

Identifiers

PMID36931723
PMCPMC10399716
OpenAlexW4327694496

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.