ArticleBMJ open2023
COllaborative Neonatal Network for the first European CPAM Trial (CONNECT): a study protocol for a randomised controlled trial.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05701514 (The COllaborative Neonatal Network for the First Congenital Pulmonary Airway Malformation), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The COllaborative Neonatal Network for the First Congenital Pulmonary Airway Malformation (CPAM) Trial
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Risk of malignant transformation and infections in congenital lung malformations in adults: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- A lifespan pooled analysis of 832 cases: characterizing the lifespan profile of clinical presentations and comorbidities in congenital pulmonary airway malformation.Orphanet journal of rare diseases · 2026Article
- Asthma in Children With Congenital Lung Malformations: A Population-Based Case-Control Study.Pediatric pulmonology · 2026Article
- 25 years of surgery in patients with congenital lung malformations: the Rotterdam experience.Pediatric surgery international · 2026Article
- Pulmonary Malignancies in Adults With Congenital Lung Malformations: A Scoping Review.JTO clinical and research reports · 2026Review
- Rising detection of congenital pulmonary airway malformations and a pragmatic institutional algorithm: a four-patient thoracoscopic case series.Journal of surgical case reports · 2026Article
- Increasing adoption of minimally invasive surgery for congenital lung malformations in young infants: a single-center experience.Frontiers in pediatrics · 2026Article
- Collaborative Efforts in Pediatric Surgery: Lessons from European Randomized Controlled Trials.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2025Review
- Timing of surgery and outcomes in patients with congenital pulmonary airway malformation: a national inpatient database study.Pediatric surgery international · 2025Article
- Congenital Pulmonary Airway Malformations: Experience of a Tunisian Tertiary Referral Center Over a Five-Year Period.Pediatric pulmonology · 2025Article
- The Diagnostics and Management of Bronchopulmonary Sequestration: An International Survey among Specialized Caregivers.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2025Article
- Natural course of CPAM and pulmonary sequestration: to operate or not to operate, this is the question.Pediatric pulmonology · 2025Review
- Respiratory Support Strategies for Surgical Neonates: A Review.Children (Basel, Switzerland) · 2025Review
- Case Report: Fiberoptic bronchoscopy and thoracoscopic surgery as a treatment for pulmonary mucormycosis in pediatric acute lymphoblastic leukemia.Frontiers in pediatrics · 2025Article
- Article
- Major surgical conditions of childhood and their lifelong implications: comprehensive review.BJS open · 2024Review
- Congenital pulmonary malformations.Turk gogus kalp damar cerrahisi dergisi · 2024Review
- Congenital lung malformations.Nature reviews. Disease primers · 2023Review
- Congenital pulmonary airway malformation in a 5 month old boy, complicated by pneumonia.Indian journal of thoracic and cardiovascular surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionConsensus is lacking on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM). For future studies, the CONNECT consortium (the COllaborative Neonatal Network for the first European CPAM Trial)-an international collaboration of specialised caregivers-has established consensus on a core outcome set of outcome parameters concerning respiratory insufficiency, surgical complications, mass effect and multifocal disease. These outcome parameters have been incorporated in the CONNECT trial, a randomised controlled trial which, in order to develop evidence-based practice, aims to compare conservative and surgical management of patients with an asymptomatic CPAM. METHODS AND ANALYSIS: Children are eligible for inclusion after the CPAM diagnosis has been confirmed on postnatal chest CT scan and they remain asymptomatic. On inclusion, children are randomised to receive either conservative or surgical management. Subsequently, children in both groups are enrolled into a standardised, 5-year follow-up programme with three visits, including a repeat chest CT scan at 2.5 years and a standardised exercise tolerance test at 5 years.The primary outcome is exercise tolerance at age 5 years, measured according to the Bruce treadmill protocol. Secondary outcome measures are molecular genetic diagnostics, validated questionnaires-on parental anxiety, quality of life and healthcare consumption-, repeated imaging and pulmonary morbidity during follow-up, as well as surgical complications and histopathology. This trial aims to end the continuous debate surrounding the optimal management of asymptomatic CPAM. ETHICS AND DISSEMINATION: This study is being conducted in accordance with the Declaration of Helsinki. The Medical Ethics Review Board of Erasmus University Medical Centre Rotterdam, The Netherlands, has approved this protocol (MEC-2022-0441). Results will be disseminated through peer-reviewed scientific journals and conference presentations. TRIAL REGISTRATION NUMBER: NCT05701514.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.