Evidence map›Paper›PMID 36931600›Full record

ArticleMucosal immunology2023

Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype.

Richard P Ramonell, Margaret Brown, Matthew C Woodruff, Joshua M Levy, Sarah K Wise, John DelGaudio, Meixue Duan, Celia L Saney, Shuya Kyu, Kevin S Cashman and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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  4. RNA NExperimental & molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Richard P RamonellDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Margaret BrownGeorgia Institute of Technology, Atlanta, Georgia, USA.
Matthew C WoodruffEmory Autoimmunity Center of Excellence, Emory University, Atlanta, Georgia, USA; Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, Georgia, USA.
Joshua M LevyDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, Georgia, USA.
Sarah K WiseDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, Georgia, USA.
John DelGaudioDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, Georgia, USA.
Meixue DuanGeorgia Institute of Technology, Atlanta, Georgia, USA.
Celia L SaneyCollege of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Shuya KyuDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, Georgia, USA.
Kevin S CashmanEmory Autoimmunity Center of Excellence, Emory University, Atlanta, Georgia, USA; Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, Georgia, USA.
Jennifer R HomEmory Autoimmunity Center of Excellence, Emory University, Atlanta, Georgia, USA; Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, Georgia, USA.
Christopher F FucileDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Informatics Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Alexander F RosenbergDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Informatics Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Christopher M TiptonEmory Autoimmunity Center of Excellence, Emory University, Atlanta, Georgia, USA; Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, Georgia, USA.
Ignacio SanzEmory Autoimmunity Center of Excellence, Emory University, Atlanta, Georgia, USA; Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, Georgia, USA.
Gregory C GibsonGeorgia Institute of Technology, Atlanta, Georgia, USA.
F Eun-Hyung LeeDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, Georgia, USA. Electronic address: f.e.lee@emory.edu.
Emory University · USGeorgia Institute of Technology · USUniversity of Alabama at Birmingham · USUniversity of Georgia · USUniversity of Pittsburgh · US

Funding

Regulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2M
Translational Training Program in Pulmonary Biology and MedicineT32HL007563 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melanie Koenigshoff · 1985 to 2026
$12.3M
Molecular Mechanisms of Human Long-lived Plasma Cell Generation in the Bone Marrow and SpleenU01AI141993 · NIAID · EMORY UNIVERSITY · PI Frances Eun-Hyung Lee · 2019 to 2026
$5.7M
The Emory Training Program in Lung HealthT32HL116271 · NHLBI · EMORY UNIVERSITY · PI BROWN, LOU ANN S, GUIDOT, DAVID MARSHALL · 2013 to 2022
$4.2M
Human Plasma Cell Maturation & Maintenance through CD138, TNFRSF, and Modulation of Ig SecretionR01AI172254 · NIAID · EMORY UNIVERSITY · PI Frances Eun-Hyung Lee · 2023 to 2026
$3.1M
Understanding Survival of Human Bone Marrow Long-Lived Plasma CellsR01AI121252 · NIAID · EMORY UNIVERSITY · PI LEE, FRANCES EUN-HYUNG · 2016 to 2020
$2.7M
NHLBI NIH HHS T32 HL007563NHLBI NIH HHS T32 HL116271NIAID NIH HHS P01 AI125180NIAID NIH HHS R01 AI121252NIAID NIH HHS R01 AI172254NIAID NIH HHS U01 AI141993
6 · The paper itself

Abstract

Immunoglobulin (Ig) E is central to the pathogenesis of allergic conditions, including allergic fungal rhinosinusitis. However, little is known about IgE antibody secreting cells (ASCs). We performed single-cell RNA sequencing from cluster of differentiation (CD)19

Indexed as

Nasal PolypsAntibody-Producing CellsHumansImmunoglobulin ENasal MucosaPhenotypeSingle-Cell AnalysisImmunoglobulin E

Identifiers

PMID36931600
PMCPMC11227847
OpenAlexW4324344465

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.