ArticleProgress in neurobiology2023
Spinal astrocytic MeCP2 regulates Kir4.1 for the maintenance of chronic hyperalgesia in neuropathic pain.
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Article in Progress in neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 28 citations in OpenAlex.
- Astrocytic ion channel Kir4.1 deficit underlies chronic pain.Neural regeneration research · 2026Article
- Targeting the PDK1/c-Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances in epigenetic regulation of potassium channels in chronic pain.Molecular biology reports · 2026Review
- Exercise training promotes nerve cell repair and regeneration after spinal cord injury.Neural regeneration research · 2026Article
- Mechanical cues as immunomodulators in neuroinflammation-driven spinal sensitization: analgesic mechanisms and therapeutic strategies.Frontiers in immunology · 2026Review
- Multifaceted Astrocyte-Neuron Cross-Talk in Neuropathic Pain: Potential Mechanisms and Functional Implications.Journal of pain research · 2026Review
- An Integrated Multi-Tissue Single-Cell Transcriptomic Analysis Highlights the CCL2-CCR2 Signaling Pathway as a Potential Therapeutic Target in Neuropathic Pain.Journal of pain research · 2026Article
- The role of gut microbiota in neuropathic pain: insights into immune mechanisms.The journal of headache and pain · 2025Review
- Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain.Nature communications · 2025Article
- Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms.International journal of molecular sciences · 2025Review
- TNF-α-preconditioning enhances analgesic efficacy of mesenchymal stem cell-derived extracellular vesicle in neuropathic painBioactive materials · 2025Article
- Reticuline modulates astrocyte and microglial responses to enhance prognosis after traumatic brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Roles of Ion Channels in Oligodendrocyte Precursor Cells: From Physiology to Pathology.International journal of molecular sciences · 2025Review
- Targeting LncRNA-Vof16: A Novel Therapeutic Strategy for Neuropathic Pain Relief.CNS neuroscience & therapeutics · 2025Article
- Preclinical Insights into the Role of Kir4.1 in Chronic Pain and Depression: Mechanisms and Therapeutic Potential.Biomolecules · 2025Review
- Spinal astrocytes involved in the pathogenesis and treatment of neuropathic pain.Frontiers in cellular neuroscience · 2025Review
- Spinal neuron-glial crosstalk and ion channel dysregulation in diabetic neuropathic pain.Frontiers in immunology · 2025Review
- Astrocytes Modulate a Specific Paraventricular Thalamus→Prefrontal Cortex Projection to Enhance Consciousness Recovery from Anesthesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Epigenetic Landscapes of Pain: DNA Methylation Dynamics in Chronic Pain.International journal of molecular sciences · 2024Review
- Study on the Mechanisms of Glrα3 in Pain Sensitization of Endometriosis.International journal of molecular sciences · 2024Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Mengchan OuDepartment of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Yali ChenDepartment of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Jin LiuDepartment of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Donghang ZhangDepartment of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Yaoxin YangDepartment of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Jiefei ShenLaboratory of Oral Diseases & National Clinical Research Center for Oral Diseases and Department of Prosthodontics, West China Stomatology Hospital of Sichuan University, Chengdu 610041, China.
Changhong MiaoDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Shao-Jun TangDepartment of Anesthesiology and The Stony Brook University Pain and Analgesia Research Center (SPARC), Stony Brook University, Stony Brook, NY 11794, USA.
Xin LiuDepartment of Anesthesiology and The Stony Brook University Pain and Analgesia Research Center (SPARC), Stony Brook University, Stony Brook, NY 11794, USA.
Daniel K MulkeyDepartments of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Tao ZhuDepartment of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: xwtao.zhu@foxmail.com.
Cheng ZhouLaboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: zhouc@163.com.
Sichuan University · CNStony Brook University · USSun Yat-sen University · CNUniversity of Connecticut · US
Funding
Wnt signaling in glial activation during HIV-associated chronic pain pathogenesisR01NS079166 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI TANG, SHAO-JUN · 2012 to 2021
$5.5MCooperative mechanisms of HIV and opiods in pain pathogenisisR01DA050530 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHUNG, JIN M, TANG, SHAO-JUN · 2019 to 2023
$3.2MNIDA NIH HHS R01 DA050530NINDS NIH HHS R01 NS079166
Abstract
Astrocyte activation in the spinal dorsal horn may play an important role in the development of chronic neuropathic pain, but the mechanisms involved in astrocyte activation and their modulatory effects remain unknown. The inward rectifying potassium channel protein 4.1 (Kir4.1) is the most important background K
Indexed as
AstrocytesNeuralgiaAnimalsHyperalgesiaKcnj10 ChannelMethyl-CpG-Binding Protein 2MiceSpinal CordSpinal Cord Dorsal HornKcnj10 ChannelMecp2 protein, mouseMethyl-CpG-Binding Protein 2Astrocyte activationChronic neuropathic painKir4.1MeCP2Neuronal sensitization
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