Evidence map›Paper›PMID 36931245›Full record

ArticleCell2023

Purification and characterization of human neural stem and progenitor cells.

Daniel Dan Liu, Joy Q He, Rahul Sinha, Anna E Eastman, Angus M Toland, Maurizio Morri, Norma F Neff, Hannes Vogel, Nobuko Uchida, Irving L Weissman

Open access · hybridAbstract read
In one paragraph

Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
22.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Glial cells in neuropathic pain.Physiological reviews · 2026
    Review
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  9. Review
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  13. Review
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  17. Isolation of postnatal human neural stem cells.bioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Daniel Dan LiuInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Joy Q HeInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Rahul SinhaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA. Electronic address: sinhar@stanford.edu.
Anna E EastmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Angus M TolandDepartment of Pathology, Stanford Medicine, Stanford, CA 94305, USA.
Maurizio MorriChan-Zuckerberg Biohub, Stanford, CA 94305, USA.
Norma F NeffChan-Zuckerberg Biohub, Stanford, CA 94305, USA.
Hannes VogelDepartment of Pathology, Stanford Medicine, Stanford, CA 94305, USA.
Nobuko UchidaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford Medicine, Stanford, CA 94305, USA. Electronic address: irv@stanford.edu.
Stanford Medicine · USChan Zuckerberg Initiative (United States) · USCalifornia Institute for Regenerative Medicine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
Medical Scientist Training ProgramT32GM145402 · NIGMS · STANFORD UNIVERSITY · PI Katrin F. Chua · 2022 to 2026
$10.0M
Stem Cell Biology, Cancer Stem Cell Biology, and Cancer ImmunotherapyR35CA220434 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2017 to 2023
$6.7M
NCI NIH HHS R35 CA220434NIGMS NIH HHS T32 GM007365NIGMS NIH HHS T32 GM145402
6 · The paper itself

Abstract

The human brain undergoes rapid development at mid-gestation from a pool of neural stem and progenitor cells (NSPCs) that give rise to the neurons, oligodendrocytes, and astrocytes of the mature brain. Functional study of these cell types has been hampered by a lack of precise purification methods. We describe a method for prospectively isolating ten distinct NSPC types from the developing human brain using cell-surface markers. CD24

Indexed as

Neural Stem CellsAnimalsAstrocytesBrainCell DifferentiationHumansMiceNeurogliaNeuronsfluorescence-activated cell sortingglial progenitor cellsindex sortingintermediate progenitor cellsneural stem cellsneurodevelopmentneuronal maturationoligodendrocyte progenitor cellsradial gliasingle-cell transcriptomics

Identifiers

PMID36931245
PMCPMC10409303
OpenAlexW4327575910

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.