ArticleResearch (Washington, D.C.)2023
Rational Design of Biological Crystals with Enhanced Physical Properties by Hydrogen Bonding Interactions.
Article in Research (Washington, D.C.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Piezoelectric amino acids and peptides: Mechanisms, molecular engineering, and biomedical applications.iScience · 2026Review
- Advances in Biomaterials Development and Their Energy Harvesting Application.Research (Washington, D.C.) · 2026Review
- Design and Manufacturing of Piezoelectric Biomaterials for Bioelectronics and Biomedical Applications.Chemical reviews · 2025Review
- Supramolecular Organic Framework with Multidimensional Storage Spaces for Ultrahigh-Capacity Iodine Capture from Seawater.Research (Washington, D.C.) · 2025Article
- The Dimensionality of Hydrogen Bond Networks Induces Diverse Physical Properties of Peptide Crystals.ACS materials letters · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen bonds are non-covalent interactions and essential for assembling supermolecules into ordered structures in biological systems, endowing crystals with fascinating physical properties, and inspiring the construction of eco-friendly electromechanical devices. However, the interplay between hydrogen bonding and the physical properties is not fully understood at the molecular level. Herein, we demonstrate that the physical property of biological crystals with double-layer structures could be enhanced by rationally controlling hydrogen bonding interactions between amino and carboxyl groups. Different hydrogen bonding interactions result in various thermal, mechanical, electronic, and piezoelectric properties. In particular, the weak interaction between O and H atoms contributes to low mechanical strength that permits important ion displacement under stress, giving rise to a strong piezoelectric response. This study not only reveals the correlation between the hydrogen bonding and physical properties in double-layer structures of biological crystals but also demonstrates the potential of these crystals as functional biomaterials for high-performance energy-harvesting devices. Theoretical calculations and experimental verifications in this work provide new insights into the rational design of biomaterials with desirable physical properties for bioelectrical devices by modulating intermolecular interactions.
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Registered trials
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