Evidence map›Paper›PMID 36930710›Full record

ArticleScience advances2023

Characterization of regional differences in resting-state fMRI with a data-driven network model of brain dynamics.

Viktor Sip, Meysam Hashemi, Timo Dickscheid, Katrin Amunts, Spase Petkoski, Viktor Jirsa

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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

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  6. Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  16. Observing hidden neuronal states in experiments.PLoS computational biology · 2025
    Article
  17. Article
  18. Deep oscillatory neural network.Scientific reports · 2025
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Viktor SipAix-Marseille Université, INSERM, Institut de Neurosciences de Systèmes (INS), Marseille, France.ORCID 0000-0002-5006-9765
Meysam HashemiAix-Marseille Université, INSERM, Institut de Neurosciences de Systèmes (INS), Marseille, France.ORCID 0000-0001-5289-9837
Timo DickscheidInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.ORCID 0000-0002-9051-3701
Katrin AmuntsInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.ORCID 0000-0001-5828-0867
Spase PetkoskiAix-Marseille Université, INSERM, Institut de Neurosciences de Systèmes (INS), Marseille, France.ORCID 0000-0003-4540-6293
Viktor JirsaAix-Marseille Université, INSERM, Institut de Neurosciences de Systèmes (INS), Marseille, France.ORCID 0000-0002-8251-8860

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Model-based data analysis of whole-brain dynamics links the observed data to model parameters in a network of neural masses. Recently, studies focused on the role of regional variance of model parameters. Such analyses however necessarily depend on the properties of preselected neural mass model. We introduce a method to infer from the functional data both the neural mass model representing the regional dynamics and the region- and subject-specific parameters while respecting the known network structure. We apply the method to human resting-state fMRI. We find that the underlying dynamics can be described as noisy fluctuations around a single fixed point. The method reliably discovers three regional parameters with clear and distinct role in the dynamics, one of which is strongly correlated with the first principal component of the gene expression spatial map. The present approach opens a novel way to the analysis of resting-state fMRI with possible applications for understanding the brain dynamics during aging or neurodegeneration.

Indexed as

Brain MappingMagnetic Resonance ImagingAgingBrainHumansRest

Identifiers

PMID36930710
PMCPMC10022900

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.