Evidence map›Paper›PMID 36930638›Full record

ArticleThe Journal of infectious diseases2023

Machine Learning Approaches to Understand Cognitive Phenotypes in People With HIV.

Shibani S Mukerji, Kalen J Petersen, Kilian M Pohl, Raha M Dastgheyb, Howard S Fox, Robert M Bilder, Marie-Josée Brouillette, Alden L Gross, Lori A J Scott-Sheldon, Robert H Paul and 1 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shibani S MukerjiMassachusetts General Hospital, Boston, Massachusetts, USA.
Kalen J PetersenWashington University in Saint Louis, Saint Louis, Missouri, USA.
Kilian M PohlStanford University, Stanford, California, USA.
Raha M DastgheybJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Howard S FoxUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.
Robert M BilderUniversity of California, Los Angeles, California, USA.
Marie-Josée BrouilletteMcGill University, Montreal, Quebec, Canada.
Alden L GrossJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Lori A J Scott-SheldonDivision of AIDS Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Robert H PaulMissouri Institute of Mental Health, University of Missouri, Saint Louis, Missouri, USA.
Dana GabuzdaDana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0002-4964-5083

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, YING · 2016 to 2025
$42.8M
Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FOX, HOWARD S · 2000 to 2021
$37.7M
TRACKING HIV INFECTION AND ALCOHOL ABUSE CNS COMORBIDITY WITH NEUROIMAGINGU01AA017347 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, SULLIVAN, EDITH VIONI · 2007 to 2021
$16.0M
NNTC Data Coordinating CenterU24MH100925 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FOX, HOWARD S, SHERMAN, SETH · 2013 to 2022
$9.5M
National Neuropsychological Network (NNN)R01MH118514 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DANIEL L DRANE, David W. Loring · 2019 to 2026
$9.4M
Machine learning to distinguish HAND from Alzheimer's disease in HIV over age 60R01MH113406 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POHL, KILIAN MARIA, VALCOUR, VICTOR · 2017 to 2021
$5.5M
Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)R01MH128868 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRICO, ADAM WAYNE, PAUL, ROBERT HARRIS · 2021 to 2025
$5.4M
Functional Imaging Reserve in NeuroHIV (FIRN)R01MH118031 · NIMH · WASHINGTON UNIVERSITY · PI ANCES, BEAU M · 2018 to 2023
$3.7M
Genetic, Imaging, and Cognition study of Positive Valence Systems in Psychotic SyndromesR01MH114152 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M, OPHOFF, ROEL A · 2018 to 2023
$3.2M
Impact of Treatment on Brain Integrity in the Earliest Stages of HIV InfectionR01MH113560 · NIMH · UNIVERSITY OF MISSOURI-ST. LOUIS · PI PAUL, ROBERT HARRIS, VALCOUR, VICTOR · 2017 to 2021
$3.1M
Relationship between methamphetamine use, viral reservoir dynamics and clinical progression in treated HIV infectionR01DA058437 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Adam Wayne Carrico, Mario Stevenson · 2023 to 2026
$2.6M
NIAAA NIH HHS U01 AA017347NIAID NIH HHS P30 AI094189NIDA NIH HHS R01 DA058437NIGMS NIH HHS U54 GM115458NIH HHS 5R01MH110259NIMH NIH HHS F32 MH129151NIMH NIH HHS K23 MH115812NIMH NIH HHS P30 MH062261NIMH NIH HHS R01 MH110259NIMH NIH HHS R01 MH113406NIMH NIH HHS R01 MH113560NIMH NIH HHS R01 MH114152NIMH NIH HHS R01 MH118031NIMH NIH HHS R01 MH118514NIMH NIH HHS R01 MH128868NIMH NIH HHS R03 MH123290NIMH NIH HHS R56 MH115853NIMH NIH HHS U24 MH100925
6 · The paper itself

Abstract

Cognitive disorders are prevalent in people with HIV (PWH) despite antiretroviral therapy. Given the heterogeneity of cognitive disorders in PWH in the current era and evidence that these disorders have different etiologies and risk factors, scientific rationale is growing for using data-driven models to identify biologically defined subtypes (biotypes) of these disorders. Here, we discuss the state of science using machine learning to understand cognitive phenotypes in PWH and their associated comorbidities, biological mechanisms, and risk factors. We also discuss methods, example applications, challenges, and what will be required from the field to successfully incorporate machine learning in research on cognitive disorders in PWH. These topics were discussed at the National Institute of Mental Health meeting on "Biotypes of CNS Complications in People Living with HIV" held in October 2021. These ongoing research initiatives seek to explain the heterogeneity of cognitive phenotypes in PWH and their associated biological mechanisms to facilitate clinical management and tailored interventions.

Indexed as

Cognition DisordersCognitive DysfunctionHIV InfectionsCognitionHumansMachine LearningPhenotypecognitive impairmentdeep learningHIVHIV-associated neurocognitive disordersmachine learning

Identifiers

PMID36930638
PMCPMC10022709

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.