Evidence map›Paper›PMID 36930636›Full record

ArticleThe Journal of infectious diseases2023

The Evolution of Assessing Central Nervous System Complications in Human Immunodeficiency Virus: Where Do We Go From Here?

Roger C McIntosh, Uraina S Clark, Mariana Cherner, Lucette A Cysique, Robert K Heaton, Jules Levin, Robert H Remien, April Thames, David J Moore, Leah H Rubin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roger C McIntoshDepartment of Psychology, University of Miami, Miami, Florida, USA.ORCID 0000-0002-1084-072X
Uraina S ClarkDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mariana ChernerDepartment of Psychiatry, University of California, San Diego, California, USA.
Lucette A CysiqueDepartment of Psychology, University of New South Wales, Sydney, Australia.
Robert K HeatonDepartment of Psychiatry, University of California, San Diego, California, USA.
Jules LevinNational AIDS Treatment Advocacy Project, New York, New York, USA.
Robert H RemienDepartment of Psychiatry, Columbia University, New York, New York, USA.
April ThamesDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
David J MooreDepartment of Psychiatry, University of California, San Diego, California, USA.
Leah H RubinDepartments of Neurology, Psychiatry and Behavioral Sciences, Epidemiology, and Molecular and Comparative Pathology, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Leah Helane Rubin · 2006 to 2026
$33.2M
Mentoring Clinical Researchers at the Intersection of NeuroHIV and Substance AbuseK24DA040550 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHERNER, MARIANA · 2015 to 2025
$1.8M
HIV-Related Changes to the Central-Autonomic Network and Associated Risk for HypertensionK01HL139722 · NHLBI · UNIVERSITY OF MIAMI CORAL GABLES · PI MCINTOSH, ROGER CHRISTOPHER · 2018 to 2022
$647k
NIDA NIH HHS K24 DA040550NIH HHS K01HL139722-05NIMH NIH HHS P30 MH062512NIMH NIH HHS P30 MH075673
6 · The paper itself

Abstract

In this fifth decade of the human immunodeficiency virus (HIV) epidemic, central nervous system (CNS) complications including cognitive impairment and mental health remain a burden for people with HIV (PWH) on antiretroviral therapy. Despite the persistence of these complications, which often co-occur, the underlying pathophysiology remains elusive and consequently treatments remain limited. To continue to grow our understanding of the underlying mechanisms of CNS complications among PWH, there is a need to reexamine our current approaches, which are now more than 2 decades old. At the 2021 National Institutes of Health-sponsored meeting on Biotypes of CNS Complications in PWH, the Neurobehavioral Working Group addressed the following: (1) challenges inherent to determining CNS complications; (2) heterogeneity in CNS complications; and (3) problems and solutions for examining integrated biotypes. The review below provides a summary of the main points presented and discussed by the Neurobehavioral Working Group at the meeting.

Indexed as

HIVHIV InfectionsCentral Nervous SystemHumanscognitive dysfunctioncomorbidityhuman immunodeficiency virusneuropsychological testingpsychosocial factors

Identifiers

PMID36930636
PMCPMC10022716

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.