Evidence map›Paper›PMID 36930635›Full record

ArticleThe Journal of infectious diseases2023

Biotypes of Central Nervous System Complications in People Living With Human Immunodeficiency Virus (HIV): National Institute of Mental Health Perspectives on Advancing the Future of HIV Healthcare.

Vasudev R Rao, Pim Brouwers, Jeymohan Joseph, Collene Lawhorn, Lori A J Scott Sheldon, Dianne M Rausch

Open access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vasudev R RaoDivision of AIDS Research, National Institute of Mental Health, Bethesda, Maryland, USA.
Pim BrouwersDivision of AIDS Research, National Institute of Mental Health, Bethesda, Maryland, USA.ORCID 0000-0002-5487-8164
Jeymohan JosephDivision of AIDS Research, National Institute of Mental Health, Bethesda, Maryland, USA.
Collene LawhornDivision of AIDS Research, National Institute of Mental Health, Bethesda, Maryland, USA.
Lori A J Scott SheldonDivision of AIDS Research, National Institute of Mental Health, Bethesda, Maryland, USA.
Dianne M RauschDivision of AIDS Research, National Institute of Mental Health, Bethesda, Maryland, USA.
Office of AIDS Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite effective suppressive antiretroviral therapy, central nervous system (CNS) complications related to human immunodeficiency virus (HIV) remain a significant problem for people with HIV (PWH). Numerous studies have contributed data to define the mechanisms underlying HIV-associated CNS pathophysiology, but causality remains elusive, with no effective therapies to prevent, reduce, or reverse HIV-associated CNS complications. Multiple physiological, clinical, cognitive, behavioral, social, and environmental factors contribute to the observed heterogeneity of adverse CNS outcomes among PWH. The National Institute of Mental Health in collaboration with investigators engaged in research related to HIV associated CNS complications organized a series of meetings to review the state of the science and facilitate the development of biologically based measures to identify the phenotypic heterogeneity of CNS outcomes linked to pathophysiology (biotypes). In this article, we summarize the proceedings of these meetings and explore the precision medicine framework to identify critical factors linked to the etiopathogenesis of CNS outcomes in PWH.

Indexed as

HIV-1HIV InfectionsCentral Nervous SystemDelivery of Health CareHumansNational Institute of Mental Health (U.S.)United StatesBiomarkersBiotypesCNS comorbid conditionsData ScienceHIVMental HealthNeuroHIVNeuroimagingNeuroimmunologyNeuropsychiatryNeurovirologyPrecision medicineViral Reservoir

Identifiers

PMID36930635
PMCPMC10226748
OpenAlexW4327681007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.