Evidence map›Paper›PMID 36930567›Full record

ArticleThe Journal of physiology2023

An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle.

Lei Yang, Rodolfo J Ricart Arbona, Carl S Smith, Kelly M Banks, V Kaye Thomas, Lawrence Palmer, Todd Evans, Romulo Hurtado

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lei YangDepartment of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY, USA.
Rodolfo J Ricart ArbonaCenter of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Carl S SmithDepartment of Urologic Surgery, University of Minnesota School of Medicine, Minneapolis, MN, USA.ORCID 0000-0003-1581-9855
Kelly M BanksDepartment of Surgery, Weill Medical College of Cornell University, New York, NY, USA.
V Kaye ThomasBio-Imaging Resource Center, The Rockefeller University, New York, NY, USA.
Lawrence PalmerDepartment of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY, USA.ORCID 0000-0001-7702-4703
Todd EvansDepartment of Surgery, Weill Medical College of Cornell University, New York, NY, USA.
Romulo HurtadoDepartment of Surgery, Weill Medical College of Cornell University, New York, NY, USA.ORCID 0000-0003-0865-3383
Cornell University · USMemorial Sloan Kettering Cancer Center · USRockefeller University · USUniversity of Minnesota · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Regulation of ENaC Trafficking and Activity in the KidneyR01DK111380 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI PALMER, LAWRENCE G · 2017 to 2025
$3.1M
Live imaging analyses of the mechanisms required for coordinated urinary tract peristalsis in lower-order and higher-order mammalian speciesR21DK116171 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HURTADO, ROMULO · 2018 to 2020
$670k
NCI NIH HHS P30 CA008748NIDDK NIH HHS R01 DK111380NIDDK NIH HHS R21 DK116171
6 · The paper itself

Abstract

Although hyperpolarization-activated cation (HCN) ion channels are well established to underlie cardiac pacemaker activity, their role in smooth muscle organs remains controversial. HCN-expressing cells are localized to renal pelvic smooth muscle (RPSM) pacemaker tissues of the murine upper urinary tract and HCN channel conductance is required for peristalsis. To date, however, the I

Indexed as

ChannelopathiesAnimalsCationsCyclic Nucleotide-Gated Cation ChannelsHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsKidneyMammalsMiceMuscle, SmoothSwineCationsCyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsHCN channelsIh funny currentpacemakersPDGFR-αperistalsisrenal pelvissmooth muscle

Identifiers

PMID36930567
PMCPMC10065941
OpenAlexW4327678710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.