Evidence map›Paper›PMID 36930527›Full record

ArticleThe Journal of clinical endocrinology and metabolism2023

Altered Emotion Perception Linked to Structural Brain Differences in Youth With Congenital Adrenal Hyperplasia.

Adam Omary, Noor Khalifeh, Devyn L Cotter, Mimi S Kim, Farzana Choudhury, Hedyeh Ahmadi, Mitchell E Geffner, Megan M Herting

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In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adam OmaryDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Noor KhalifehDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Devyn L CotterDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Mimi S KimCenter for Endocrinology, Diabetes, and Metabolism, and The Saban Research Institute at Children's Hospital Los Angeles; Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Farzana ChoudhuryDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Hedyeh AhmadiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Mitchell E GeffnerCenter for Endocrinology, Diabetes, and Metabolism, and The Saban Research Institute at Children's Hospital Los Angeles; Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Megan M HertingDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.ORCID 0000-0002-0840-4582

Funding

The Influence of Fetal Testosterone on Emotional Processing, Amydala Neurocircuitry, and Risk for Affective Disorders in ChildhoodK01MH108761 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HERTING, MEGAN MARIE · 2016 to 2019
$726k
Brain and Adipose Contributors to Food Seeking in Youth with Adrenal HyperplasiaK23HD084735 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KIM, MIMI SUSAN · 2016 to 2018
$474k
NICHD NIH HHS K23 HD084735NIH HHS K01 MH1087610NIMH NIH HHS K01 MH108761
6 · The paper itself

Abstract

contextCongenital adrenal hyperplasia (CAH) is a genetic disorder that results in hormonal imbalances and decreased brain volumes in regions important for emotional processing.

objectiveTo examine whether emotion perception differs between youth with CAH and control youth, and if these differences relate to brain volumes.

methodsIn this cross-sectional study of 27 youths with CAH (mean age = 12.63 years, 16 female) and 35 age- and sex-matched controls (mean age = 13.03 years, 20 female), each participant rated picture stimuli and completed a 3T structural brain scan. Valence and arousal ratings and reaction times of 61 affective images were assessed. Gray matter volumes were measured by MRI.

resultsYouth with CAH had lower valence ratings for negative (P = .007) and neutral (P = .019) images. Controls showed differences in reaction times and arousal ratings across stimuli conditions, but youth with CAH did not. Brain volumes of the right amygdala (P = .025) and left hippocampus (P = .002) were associated with valence ratings. Left rostral middle frontal (P < .001) and right medial orbitofrontal cortex (P = .002) volumes were negatively related to valence scores only in youth with CAH, whereas left medial orbitofrontal cortex (P < .001) volumes were associated with valence scores positively in youth with CAH and negatively in controls.

conclusionFindings suggest that youth with CAH perceive emotive stimuli as more unpleasant. Decreased brain volumes in the amygdala, hippocampus, and prefrontal cortex are associated with these measures of altered emotion perception in youth with CAH.

Indexed as

Adrenal Hyperplasia, CongenitalAdolescentBrainChildCross-Sectional StudiesEmotionsFemaleHumansMagnetic Resonance ImagingPerceptionadrenal insufficiencybraincongenital adrenal hyperplasiaemotion perceptionmagnetic resonance imagingneuroimaging

Identifiers

PMID36930527
PMCPMC10505548

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.