ArticleeLife2023
Asymmetric retinal direction tuning predicts optokinetic eye movements across stimulus conditions.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 16 citations in OpenAlex.
- Temporally segregated functions for Gfi1 in the development and maintenance of direction selectivity in the vertebrate retina.Current biology : CB · 2026Article
- The mechanotransduction channel Piezo2 refines axonal projections to the accessory optic system and regulates the optokinetic reflex.bioRxiv : the preprint server for biology · 2026Article
- Filter, Detector, Predictor: The expanding repertoire of retinal computation in vertebrates.Vision research · 2026Review
- An inhibitory brainstem pathway reduces visual detection during background motion.Nature communications · 2026Article
- Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors.Science robotics · 2025Article
- Slit2/Robo1 signaling constrains image stabilization responses to preserve ethologically favorable directional asymmetry.Current biology : CB · 2025Article
- Activity-dependent development of synaptic circuits mediates direction selectivity in an axis-specific manner.Cell reports · 2025Article
- Strabismus and nystagmus in oculocutaneous albinism: clinical perspectives, diagnosis, and role of neurotransmitters.Neurogenetics · 2025Review
- Asymmetries in the Architecture of ON and OFF Arbors in ON-OFF Direction-Selective Ganglion Cells.The Journal of comparative neurology · 2025Article
- Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentation.Cell reports. Medicine · 2024Article
- Tau P301S Transgenic Mice Develop Gait and Eye Movement Impairments That Mimic Progressive Supranuclear Palsy.bioRxiv : the preprint server for biology · 2024Article
- Transformation of Motion Pattern Selectivity from Retina to Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- PyOKR: A Semi-Automated Method for Quantifying Optokinetic Reflex Tracking Ability.Journal of visualized experiments : JoVE · 2024Article
- Contrast Sensitivity of ON and OFF Human Retinal Pathways in Myopia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Asymmetric retinal direction tuning predicts optokinetic eye movements across stimulus conditions.eLife · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Across species, the optokinetic reflex (OKR) stabilizes vision during self-motion. OKR occurs when ON direction-selective retinal ganglion cells (oDSGCs) detect slow, global image motion on the retina. How oDSGC activity is integrated centrally to generate behavior remains unknown. Here, we discover mechanisms that contribute to motion encoding in vertically tuned oDSGCs and leverage these findings to empirically define signal transformation between retinal output and vertical OKR behavior. We demonstrate that motion encoding in vertically tuned oDSGCs is contrast-sensitive and asymmetric for oDSGC types that prefer opposite directions. These phenomena arise from the interplay between spike threshold nonlinearities and differences in synaptic input weights, including shifts in the balance of excitation and inhibition. In behaving mice, these neurophysiological observations, along with a central subtraction of oDSGC outputs, accurately predict the trajectories of vertical OKR across stimulus conditions. Thus, asymmetric tuning across competing sensory channels can critically shape behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.