Evidence map›Paper›PMID 36929925›Full record

ArticleACS synthetic biology2023

Indirect Enrichment of Desirable, but Less Fit Phenotypes, from a Synthetic Microbial Community Using Microdroplet Confinement.

Ramya Ganiga Prabhakar, Gaoyang Fan, Razan N Alnahhas, Andrew J Hirning, Matthew R Bennett, Yousif Shamoo

Open access · greenAbstract read
In one paragraph

Article in ACS synthetic biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ramya Ganiga PrabhakarDepartment of Biosciences, Rice University, Houston, Texas 77005, United States.ORCID 0000-0001-6233-0396
Gaoyang FanDepartment of Mathematics, University of Houston, Houston, Texas 77204, United States.ORCID 0000-0001-6149-2131
Razan N AlnahhasDepartment of Biosciences, Rice University, Houston, Texas 77005, United States.
Andrew J HirningDepartment of Biosciences, Rice University, Houston, Texas 77005, United States.
Matthew R BennettDepartment of Biosciences, Rice University, Houston, Texas 77005, United States.ORCID 0000-0002-4975-8854
Yousif ShamooDepartment of Biosciences, Rice University, Houston, Texas 77005, United States.ORCID 0000-0001-9241-8962
Rice University · USUniversity of Houston · US

Funding

Defining Evolutionary Trajectories: Molecular adaptation to antibiotic resistanceR01AI080714 · NIAID · RICE UNIVERSITY · PI SHAMOO, YOUSIF · 2009 to 2023
$4.3M
Dynamics and pattern formation in differentiating cellular populationsR01GM144959 · NIGMS · RICE UNIVERSITY · PI BENNETT, MATTHEW R. · 2021 to 2024
$1.2M
NIAID NIH HHS R01 AI080714NIGMS NIH HHS R01 GM144959
6 · The paper itself

Abstract

Spatial structure within microbial communities can provide nearly limitless opportunities for social interactions and are an important driver for evolution. As metabolites are often molecular signals, metabolite diffusion within microbial communities can affect the composition and dynamics of the community in a manner that can be challenging to deconstruct. We used encapsulation of a synthetic microbial community within microdroplets to investigate the effects of spatial structure and metabolite diffusion on population dynamics and to examine the effects of cheating by one member of the community. The synthetic community was composed of three strains: a "Producer" that makes the diffusible quorum sensing molecule (

Indexed as

4-ButyrolactoneLactonesQuorum Sensing4-ButyrolactoneLactones

Identifiers

PMID36929925
PMCPMC11259032
OpenAlexW4327684318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.