Evidence map›Paper›PMID 36929807›Full record

ArticleCell transplantation

Anala Shetty, Seunghyun Lim, Phoebe Strell, Clifford J Steer, Juan Carlos Rivera-Mulia, Walter C Low

Open access · goldAbstract read
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Recent advances in interspecies chimeras and organogenesis.Current opinion in genetics & development · 2025
    Review
  3. Review
  4. Advances in single-cell transcriptomics in animal research.Journal of animal science and biotechnology · 2024
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anala ShettyMolecular, Cellular, Developmental Biology, and Genetics Graduate Program, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-1185-3183
Seunghyun LimBioinformatics and Computational Biology Graduate Program, University of Minnesota, Minneapolis, MN, USA.
Phoebe StrellComparative and Molecular Biosciences Graduate Program, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-1700-015X
Clifford J SteerMolecular, Cellular, Developmental Biology, and Genetics Graduate Program, University of Minnesota, Minneapolis, MN, USA.
Juan Carlos Rivera-MuliaMolecular, Cellular, Developmental Biology, and Genetics Graduate Program, University of Minnesota, Minneapolis, MN, USA.
Walter C LowMolecular, Cellular, Developmental Biology, and Genetics Graduate Program, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8593-0175
University of Minnesota · US

Funding

Generating Exogenic Hippocampal Neural Cells via Blastocyst Complementation for Transplantation in Alzheimer's Disease.R01DK117286 · NIDDK · UNIVERSITY OF MINNESOTA · PI STEER, CLIFFORD JOHN · 2018 to 2021
$2.4M
Regulatory elements of replication timing and 3D genome organizationR35GM137950 · NIGMS · UNIVERSITY OF MINNESOTA · PI RIVERA-MULIA, JUAN CARLOS · 2020 to 2024
$2.3M
NIDDK NIH HHS R01 DK117286NIGMS NIH HHS R35 GM137950
6 · The paper itself

Abstract

Currently, there is a significant shortage of transplantable organs for patients in need. Interspecies chimerism and blastocyst complementation are alternatives for generating transplantable human organs in host animals such as pigs to meet this shortage. While successful interspecies chimerism and organ generation have been observed between evolutionarily close species such as rat and mouse, barriers still exist for more distant species pairs such as human-mouse, marmoset-mouse, human-pig, and others. One of the proposed barriers to chimerism is the difference in developmental stages between the donor cells and the host embryo at the time the cells are introduced into the host embryo. Hence, there is a logical effort to stage-match the donor cells with the host embryos for enhancing interspecies chimerism. In this study, we used an

Indexed as

CallithrixPluripotent Stem CellsAnimalsBlastocystChimerismEmbryo, MammalianHumansMiceRatsSwinecorrelation analysisearly embryonic developmentinterspecies chimerismscRNA-seq analysisstage-matching

Identifiers

PMID36929807
PMCPMC10026093
OpenAlexW4327675621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.