Evidence map›Paper›PMID 36929675›Full record

ReviewCell proliferation2023

Vascularized organ bioprinting: From strategy to paradigm.

Heran Wang, Xin Liu, Qi Gu, Xiongfei Zheng

Abstract readReview
In one paragraph

Review in Cell proliferation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Future Frontiers in Bioinspired Implanted Biomaterials.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  3. Extrusion bioprinting: meeting the promise of human tissue biofabrication?Progress in biomedical engineering (Bristol, England) · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Heran WangState Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China.ORCID https://orcid.org/0000-0003-3321-4438
Xin LiuState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-5334-6457
Qi GuState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-9387-9525
Xiongfei ZhengState Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China.ORCID https://orcid.org/0000-0001-9756-1119

Funding

CAS Project for Young Scientists in Basic Research YSBR-041National Natural Science Foundation of China 51875557National Natural Science Foundation of China 52205319the Foundation of State Key Laboratory of Robotics 2023-Z01The Foundation of State Key Laboratory of Robotics 2022-Z01The Foundation of State Key Laboratory of Robotics 2023-Z01the National Key Research and Development Program of China SQ2020YFB130100The National Key Research and Development Program of China SQ2020YFB130100the Research Equipment Development Program of CAS YJKYYQ20170042the Research Equipment Development Program of CAS YJKYYQ20190045The Research Equipment Development Program of CAS YJKYYQ20170042The Research Equipment Development Program of CAS YJKYYQ20190045the Strategic Priority Research Program of CAS XDA16020803The Strategic Priority Research Program of CAS XDA16020803
6 · The paper itself

Abstract

Over the past two decades, 3D bioprinting has become a popular research topic worldwide, as it is the most promising approach for manufacturing vascularized organs in vitro. However, transitioning from bioprinting of simple tissue models to real biomedical applications is still a challenge due to incomplete interdisciplinary theoretical knowledge and imperfect multi-technology integration. This review examines the goals of vasculature manufacturing and proposes new strategic objectives in three stages. We then outline a bidirectional manufacturing strategy consisting of top-down reconstruction (bioprinting) and bottom-up regeneration (cellular behaviour). We also provide an in-depth analysis of the four aspects of design, ink, printing and culture. Furthermore, we present the 'construction-comprehension cycle' research paradigm and the 'math-model-based batch insights generator' research paradigm for the future, which may have the potential to revolutionize the biomedical field.

Indexed as

BioprintingTissue EngineeringPrinting, Three-Dimensional

Identifiers

PMID36929675
PMCPMC10212711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.