Evidence map›Paper›PMID 36929462›Full record

ArticleJournal of molecular neuroscience : MN2023

Association Analysis of 27 Single Nucleotide Polymorphisms in a Chinese Population with Essential Tremor.

Lanxiao Cao, Luyan Gu, Jiali Pu, Dayao Lv, Jun Tian, Xinzhen Yin, Ting Gao, Zhe Song, Jinyu Lu, Gaohua Zhao and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Lanxiao CaoDepartment of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Luyan GuDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jiali PuDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Dayao LvDepartment of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jun TianDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xinzhen YinDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ting GaoDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhe SongDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jinyu LuDepartment of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Gaohua ZhaoDepartment of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Baorong ZhangDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yaping YanDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. yanyaping@zju.edu.cn.
Guohua ZhaoDepartment of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. gzhao@zju.edu.cn.ORCID http://orcid.org/0000-0003-0593-9175
Second Affiliated Hospital of Zhejiang University · CN

Funding

Key Projects of Zhejiang Provincial Natural Science Fund Z23H090007Medical and Health Research Project of Zhejiang Province 2020RC061Medical and Health Research Project of Zhejiang Province 2021RC065Medical and Health Research Project of Zhejiang Province 2023KY838Medical Science and Technology Project of Zhejiang Province WKJ-ZJ-2208National Natural Science Foundation of China 82001353
6 · The paper itself

Abstract

Genetic factors play a major role in essential tremor (ET) pathogenesis. This study aimed to assess variant burden in ET-associated genes in a relatively large Chinese population cohort. We genotyped 27 single nucleotide polymorphisms (SNPs) previously reported to be associated with ET by multiplex PCR amplicon sequencing assay in 488 familial and sporadic ET patients and 514 healthy controls (HCs). Then, we performed allelic and genotypic association test by Pearson chi-square test or Fisher's exact test. A total of 1002 samples were included in our analysis, consisting of 488 ET patients and 514 sex and age-matched HCs. For rs10937625, the C allele was linked to increased risk of ET (P = 0.019, OR = 1.503, 95% CI = 1.172-1.928). The carriers of the C/C homozygote and C/T heterozygote showed a significantly higher risk of ET, compared with the T/T homozygote under the dominant model (P = 0.019, OR = 1.628, 95% CI = 1.221-2.170). There were no statistically significant differences in the frequency of other SNPs between ET patients and healthy controls. Rs10937625 (STK32B) may increase the risk of ET in eastern Chinese population.

Indexed as

Essential TremorGenetic Predisposition to DiseaseCase-Control StudiesChinaEast Asian PeopleGene FrequencyGenotypeHumansPolymorphism, Single NucleotideProtein Serine-Threonine KinasesProtein Serine-Threonine KinasesSTK32B protein, humanEssential tremorGeneMovement disordersSingle nucleotide polymorphisms (SNPs)STK32B

Identifiers

PMID36929462
OpenAlexW4327683107

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.