ArticleJournal of endocrinological investigation2023
The importance of hypophosphatemia in the clinical management of primary hyperparathyroidism.
Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- Renal calcifications and primary hyperpara-thyroidism in a tertiary care hospital center of North Africa: a single-center experience.Medicine and pharmacy reports · 2026Article
- Phosphate handling as a determinant of osteoporosis in primary hyperparathyroidism.Endocrine connections · 2026Article
- Observational
- Hypophosphatemia in the Diagnosis and Management of Primary Hyperparathyroidism.Journal of clinical medicine · 2025Article
- The impact of hypophosphatemia on biochemical profile and renal outcomes in primary hyperparathyroidism: a nationwide retrospective study.Turkish journal of medical sciences · 2025Article
- Skeletal phenotypes in postmenopausal women affected by primary hyperparathyroidism.Frontiers in endocrinology · 2024Article
- Association between waist-to-height ratio and osteoporosis in the National Health and Nutrition Examination Survey: a cross-sectional study.Frontiers in medicine · 2024Article
- The Impact of Moderate Hypophosphatemia on the Clinical Management of Primary Hyperparathyroidism.Cureus · 2023Article
- Assessing causal associations of hyperparathyroidism with blood counts and biochemical indicators: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe levels of serum phosphorus (P) are low or low-normal in primary hyperparathyroidism (PHPT), and there is an inverse relationship between the levels of parathormone (PTH) and P. However, when considering the diagnostic and surgical indication criteria of PHPT, serum P levels are generally ignored. The aim of this study was to retrospectively evaluate the association of serum P levels with the clinical outcomes of PHPT. MATERIALS AND
methodsA retrospective evaluation was made of the data of 424 consecutive patients (370 females, 54 males) with PHPT who presented at our centre.
resultsThe mean age of the study population was 57 ± 11.68 years. The mean P was 2.57 ± 0.53 mg/dl. Asymptomatic disease was determined in 199 (47%) patients. Male patients had significantly lower levels of P. Symptomatic patients and patients with renal stones, vitamin D < 20 µg/l, calcium level ≥ 11.2 mg/dl, 24 h urinary calcium > 400 mg/day, or hypomagnesemia, were seen to have significantly lower levels of P (p < 0.05). Hypophosphatemia (hypoP) was found in 202 of 424 patients (47%), and these patients had a higher rate of symptomatic disease (63% to 44%, p < .0001). Of the 61 (88%) patients with moderate hypoP, 54 (88%) had at least one of the surgical criteria. A statistically significant increase in the incidence of hypoP was determined in symptomatic and male patients. In the patients with hypoP, serum PTH and urine calcium levels were found to be higher, and lumbar T-scores and serum vitamin D levels were lower. The patients with hypoP had higher rates of renal stones and osteoporosis (p < 0.05).
conclusionsThe current study results show that hypoP is associated with a higher risk of osteoporosis and renal stones in PHPT patients. Even if patients are asymptomatic, moderate hypoP may be associated with poor outcomes of PHPT. Therefore, moderate hypoP may be a new criterion for parathyroidectomy, regardless of hypercalcemia level.
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